Otology
Radixin deficiency causes deafness via cochlear stereocilia degeneration
Published in Blood Weekly, November 11th, 2004
According to recent research published in the Journal of Cell Biology, "Ezrin/radixin/moesin (ERM) proteins cross-link actin filaments to plasma membranes to integrate the function of cortical layers, especially microvilli.
"We found that in cochlear and vestibular sensory hair cells of adult wildtype mice, radixin was specifically enriched in stereocilia, specially developed giant microvilli, and that radixin-deficient (Rdx-/-) adult mice exhibited deafness but no obvious vestibular dysfunction."
"Before the age of hearing onset...
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Source: Blood Weekly (2004-11-11)
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