HIV/AIDS Research

Model developed to study function of HIV-infected monocyte-derived macrophages

Published in Blood Weekly, November 18th, 2004

A model was developed to study the function of HIV-infected monocyte-derived macrophages.

Investigators in the United States have "developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter.

"Although it harbors a noninfectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response alterations and pathologies similar to humans can be observed."

"Regulation of HIV-1 expression is influenced by various cellular factors and it is well known that macrophages are one of the major reservoir...

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Source: Blood Weekly (2004-11-18)

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