Blood Weekly

Blood Banking - SC refrigeration is simple option for autotransplants within few days of harvest

Congenital Hypothyroidism - High prevalence of parental consanguinity in infants with permanent CH

HIV/AIDS Epidemiology - Use of blood donor data for HIV surveillance does not reflect normal population

Stem Cell Research - Telomerase maintained in self-renewing tissues during serial regeneration

Stem Cell Transplant-Related Aspergillosis - Aspergillosis occurs later after reduced intensity versus regular SCT

Anti-Infective Agents - Sulfamates offer promise as anti-infective/anticancer agents

Anti-Inflammatory Agents - Resveratrol has novel nonsteroidal anti-inflammatory properties

Antiretroviral Therapy - Antiretroviral CSF penetration improves cognitive disorders in HIV infection

Antiviral Drug Development - Rab9 identified as a novel antiviral drug target

Apoptosis - Capillin induces apoptosis in tumor cells

Apoptosis - HTLV-1 Tax oncogene causes tumorigenesis

Arsenic Contamination - Reducing arsenic contamination often increases water-related infectious diseases

Artificial Blood - Loyola joins artificial blood study; patients to be tested without permission

Blood Banking - Diagnostic company launches blood bank educational initiative

Bone Marrow Transplantation - Bone marrow found for woman seeking South Asian donors

Bone Marrow Transplantation - Patients with impaired LV ejection fraction can achieve long-term survival

Bone Marrow Transplantation - Psychosocial/behavioral variables do not effect 1-year survival after BMT

Botulism - Eighty percent of botulism outbreaks attributed to home-preserved vegetables

Bovine Spongiform Encephalopathy - Scientists raise concerns about second wave of 'mad cow' prion infection

Business Update - Curative Health Services opens new Critical Care Systems' branch locations

Cancer Therapy - QUADRAMET data presented at Prostate Cancer Foundation scientific retreat

Caprine Arthritis Encephalitis Virus - Caprine arthritis encephalitis virus isolated from sheep during epidemic

Cardiac Surgery - Blood flow monitoring system could reduce risks during surgery

Cardiology - A new thrombosis and angiogenesis signaling pathway has diagnostic value

Cardiology - Antiplatelet agent slated for new Phase III trial

Cardiology - Kensey Nash provides update on TriActiv System FDA approval status

Collaborations - Companies announce collaboration for novel TFPI peptides

Colon Cancer - Novel Bcl-2 family gene associated with progression of colon cancer

Colon Cancer - Targeted therapy + efficient chemotherapy increases colorectal cancer survival

Colorectal Cancer - Excessive alcohol intake plus low folate increase risk of colorectal cancer

Complementary & Alternative Medicine - Studies suggest green tea/tea polyphenols lower cancer risk/inhibits tumors

Creutzfeldt-Jakob Disease - Scientists raise concerns about second wave of "mad cow" prion infection

Cytomegalovirus - Human cytomegalovirus-induced host cell enlargement is iron dependent

DNA Research - Automated scoring procedure developed for micronucleus test

Dermatology - Cells expressing nestin-driven marker model early skin angiogenesis

Diagnostics - A new assay improves the timeliness and sensitivity of hepatitis C detection

Diagnostics - Counting immunoassay detects hepatitis markers in whole-blood samples

Diagnostics - Novel method detects/quantitates hemoglobin-based oxygen carriers in plasma

Drug-Resistant Enterococcus - Vancomycin-resistant E. facecalis disseminated between hospitals 100 km apart

Drug-Resistant Staphylococcus Aureus - Molecular monitoring determines nosocomial dissemination of MSRA

Endocrinology - Combined oral contraceptives affect activated protein C resistance

Environmental Health - A long wait for Love Canal health study that promises no answers

Epidemiology - Human disease outbreaks are bioindicators of ecologic well-being

Epidemiology - The minimum spanning tree model tracks the source of hepatitis C outbreaks

Epstein-Barr Virus - Rheumatoid factors induce signaling from B cells and lead to EBV activation

Finance - Biotech stem cell-focused company raises $22.5 million in new equity financing

Finance - U.S. FDA approval of FOSRENOL triggers US$18 million payment

Formaldehyde Exposure - Formaldehyde-induced DNA adducts biomarkers of nasal cell formaldehyde exposure

Genital Herpes - Viral shedding explored as a surrogate marker for genital herpes transmission

Glioblastoma - 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells

HIV/AIDS Drug Resistance - Incomplete HIV suppression may account for resistant mutations in brain

HIV/AIDS Genetics - HIV-1 recombination is a major evolutionary force affecting genetic variation

HIV/AIDS Pathogenesis - Non-syncytia-inducing HIV inhibits replication of syncytia-inducing strains

HIV/AIDS Perinatal Transmission - Nevirapine does not prevent perinatal HIV-1 transmission in the field

HIV/AIDS Research - 2-Aminopurine fluorescence binding assay quantitates HIV-1 TAR interactions

HIV/AIDS Research - CD4 infection with infectious HIV-1 leads to IL-2 promoter hyper-responsiveness

HIV/AIDS Research - CD4+ cell loss in T-tropic HIV-1 infection is not directly mediated by apoptosis

HIV/AIDS Research - Conserved carboxy terminus of HIV-1 Gag important for virion assembly/release

HIV/AIDS Research - Cyoplasmic p53 may enhance the accuracy of HIV-1 RT DNA synthesis

HIV/AIDS Research - Determinants within gp120 and gp41 contribute to CD4 independence of SIV Env

HIV/AIDS Research - HIV-1 integration sites flanked by potential MARs can act as promoters

HIV/AIDS Research - HIV-infected CD8 lymphocytes generated through infection of activated CD8 cells

HIV/AIDS Research - Hsp70 protects cells from cell cycle arrest and apoptosis induced by HIV-1 Vpr

HIV/AIDS Research - IgMs selectively cleave HIV gp120 by a nucleophilic mechanism

HIV/AIDS Risk - Adolescent woman may be more susceptible to HIV infection than men in Cameroon

HIV/AIDS Screening - HIV screening inadequate in North Carolina jails

HIV/AIDS Therapy - Antiretroviral treatment decisions based on toxicity/resistance/convenience

HIV/AIDS Therapy - Each nucleoside/nucleotide backbone of HIV therapy has its advantages

HIV/AIDS Therapy - HIV viral load after 4 weeks of HAART predicts virologic outcome at 24 weeks

HIV/AIDS Therapy - Improved activity of abacavir prodrug due to increased CBV-TP metabolites

HIV/AIDS Therapy - Mechanism elucidated for bleomycin inhibition of HIV-1

HIV/AIDS Therapy - NRTIs decrease mitrochondrial DNA synthesis and oxidative enzyme content

HIV/AIDS Therapy - Quality of life increased with enfuvirtide plus optimized background regimen

HIV/AIDS Therapy - Safety data should not be extrapolated from early to new HIV protease inhibitors