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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . December 2nd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Cardiac Biomarker - Cardiac troponins/NT-proBNP prognostic of amyloidosis PBSCT survival

Ganciclovir - Ganciclovir less toxic to myeloid SCs from cord blood than from bone marrow

Tissue Engineering - Hyaluronic acid-based scaffolds may stimulate heart valve tissue formation

Tissue Regeneration - Novel system allows characterization of scaffolds for soft tissue regeneration

Umbilical Cord Blood - Novel cord blood cells identified with hematopoietic/chondrocytic potential

AL Amyloidosis - High-dose melphalan and ASCT improves quality of life of AL amyloidosis patients

Acute Lymphoblastic Leukemia - Advances in ALL treatment may lead to elimination of irradiation

Acute Myelogenous Leukemia - AML samples with FLT3/ITD mutations preferentially killed by FLT3 inhibition

Acute Myeloid Leukemia - Idarubicin and busulfan feasible for elderly AML patients undergoing ASCT

Anti-inflammatory Effects - Inhaled CO has anti-inflammatory effects against ventilator-induced lung injury

Apoptosis - M4N induces growth arrest/apoptosis by inhibiting Cdc2 and survivin expression

Aspergillosis - Aspergillosis: Emerging infection in critically ill patients without malignancy

Bacterial Resistance - Indian Salmonella Typhi isolates have reduced ciprofloxacin susceptibility

Bacteriology - Pneumococcal virulence factor contributions to pathogenesis studied in mice

Basal Cell Carcinoma - Basal cell carcinoma rates continuously increasing in the Netherlands since 1973

Biotechnology - MTT/ATP/calcein assays similarly predict potency of cytotoxic anticancer agents

Blood Collection - Company enters blood-bank market with new Lasette

Bone Marrow Failure - Murine model developed for bone marrow failure

Bone Marrow Transplantation - Suicide gene constructs may be effective graft-versus-leukemia therapy

Breast Cancer - Antiestrogenic DTACs inhibit estrogen receptor alpha-mediated transcription

Burkholderia Cepacia - No correlation between B. cepacia complex wbiI RFLP genotype and species

Burkitt Lymphoma - Intensive/short-term Burkitt lymphoma chemotherapy effective/manageable toxicity

Business & Finance - ATryn maker reports third-quarter net loss of $7.2 million

Business & Finance - Haemonetics makes equity investment, enters research collaboration

Calcivirus Inactivation - Nonionizing and ionizing radiation inactivate Calicivirus

Cancer Vaccine - PHB1/PHB2 identified as blood-borne tumor antigens

Cardiopulmonary Bypass - Deleterious hematological effects of CBP centrifugal pumps compared

Cardiovascular Health - Thrombin inhibitor used in coronary intervention lowers costs, study shows

Celiac Disease Epidemiology - Celiac disease prevalence higher in Turkish population compared to Western world

Central Nervous System Disease - Stem cell focused biotech completes equity financing to support clinical trial

Cigarette Smoke - Low levels of cigarette smoke induce irreversible change in cell chromosomes

Clostridium Perfringens - Cpe-positive Clostridium perfringens spores from feces isolated/enumerated

Community-Associated Infection - Risk of community-associated MRSA infection is associated with several factors

Coronary Angioplasty - Thrombolytic therapy and angioplasty can effectively achieve cardiac reperfusion

Cytomegalovirus Infection - Oral valganciclovir equivalent to oral ganciclovir for CMV prevention

Diagnostics - Lab designer's hematology analyzers ranked best in industry by consulting firm

Diagnostics - LightCycler PCR assay detects/characterizes enterotoxigenic Escherichia coli

Dialysis - Medical equipment, renal device companies partner to manufacture dialysis system

Ebola Virus - Blood samples from fatal and nonfatal cases of Ebola infection analyzed

Enzymology - Virus-mediated therapy corrects acute intermittent porphyria in murine models

Erythropoietin - Transgenic EPO expression overcomes lethality caused by c-Kit(w/w) mutation

Familial Amyloidotic Polyneuropathy - Successful fatherhood, pregnancy possible for liver-transplanted FAP patients

Finance - Dialysis company reports Q3 income of $55.3 million

Graft-versus-Host Disease - Cyclosporin and MMF for GVHD prophylaxis associated with faster engraftment

Graft-versus-Host Disease - Valpha24+ NK cell number after HSCT may be related to the development of GVHD

HIV/AIDS & Tuberculosis - HIV has less effect on point prevalence of TB disease than on TB incidence

HIV/AIDS & Tuberculosis - Strategy developed to decrease global burden of TB/HIV

HIV/AIDS Diagnostics - Rapid field test sensitive and specific for detecting/differentiating HIV types

HIV/AIDS Diagnostics - Simple and reproducible assay developed to screen HIV-1 subtypes

HIV/AIDS Immunology - Persistent immune deficit in some patients irrespective of HIV viral load

HIV/AIDS Infection - Association between dual HIV-1 infection and elevated viral load set point

HIV/AIDS Pathogenesis - Toll-like receptor 2 stimulation may contribute to HIV immunopathogenesis

HIV/AIDS Research -  E. bieneusi genotype D spores transmitted to SIV-infected macaques

HIV/AIDS Research - HIV-1 viral load not associated with intrapatient quasispecies heterogeneity

HIV/AIDS Research - Heat-shock protein 70 coprecipitates with Vpr from HIV-1-infected macrophages

HIV/AIDS Research - High-throughput assay identifies CCR5/CD4-mediated HIV virus entry inhibitors

HIV/AIDS Screening - Chinese blood centers to use rapid HIV Tests

HIV/AIDS Therapy - HIV-1 integrase nuclear import inhibited by styrylquinoline derivatives

HIV/AIDS Therapy - Lopinivir efficacy decreases following cotransfection of wild-type HIV clones

HIV/AIDS Therapy - Protease inhibitor fosamprenavir potent against advanced HIV disease

HIV/AIDS Therapy - Trim5-cyclophilin A fusion protein from owl monkey kidney cells restricts HIV-1

HIV/AIDS-Related Apoptosis - Altered TNFSF CD95 receptor expression reduces B cell survival in HIV infection

HIV/AIDS-Related Drug Resistance - Wild-type breast cancer resistance protein induces cellular resistance to NRTIs

HIV/AIDS-Related Infection - Protothecal arthritis and tenosynovitis resulted from hematogenous dissemination

HIV/AIDS-Related Transmission - HIV viral load increases in breast milk following ZDV discontinuation

Heart Failure - Patients with heart failure on coumarin should be closely monitored

Helicobacter Pylori - IL-1 receptor-1 gene polymorphism associated with increased H. pylori risk

Hematology - Imatinib does not normalize blood dendritic cell levels in leukemia patients

Hematopoiesis - DC production in myelodysplastic syndrome results in ineffective dendritopoiesis

Hemochromatosis - IgG treatment in pregnancy reduces severity of rare liver condition in newborns

Hemophilia - Factor IX launched for the treatment of hemophilia B in Spain

Hepatitis B - European authorities give positive opinion for Fendrix vaccine

Hepatitis Therapy - Drug combination shows promise in treating hepatitis C

Immunology - CD46-mediated costimulation enhances early TCR/CD3 signaling in CD4+ cells

Influenza A Pathogenesis - Hemagglutinin of 1918 pandemic influenza A virus confers enhanced pathogenicity

Inotropic Support - Report describes the keys to weaning patients from inotropic support.

Invasive Aspergillosis - Lower cut-off proposed for galactomannan detection in neutropenic/SCT patients

Ischemia - Generation of NO from NO2 by xanthine oxidoreductase protects the myocardium

Kaposi Sarcoma-Associated Herpesvirus - Kaposi sarcoma-associated herpesvirus transmission likely via saliva

Kidney Stem Cells - Renal papilla is a niche for kidney stem cells

Kidney Transplantation - Abnormal relapse of atypical hemolytic uremic syndrome described

Klebsiella Pneumoniae - Intubation/prematurity risk factors for neonatal K. pneumoniae infection

Leishmaniasis - Zymodemes identified from isoenzyme analysis of Leishmania strains in France

Leukemia - Leukemic fusion gene AME suppresses CEBPA in AML by calreticulin activation

Leukemia - Researcher studying new form of anticancer drug resistance in leukemia cells

Leukemia - Risk of blood cancer high in older obese women

Leukemia Therapy - Gemtuzumab ozogamicin effective in relapsed APL patients

Liposomal Delivery - Novel RGD lipopeptides target liposomes to integrin-expressing melanoma cells

Liver Transplantation - Hemodynamic factors limit the outcomes of liver candidates with low MELD scores

Lymphoma - Higher survival with BEAM conditioning regimen over CEB in lymphoma patients

Melanocytes - PI3K mediates protection against TRAIL-induced apoptosis in melanocytes

Melanoma - Lonidamine plus radiation increase melanoma cell apoptosis

Melanoma - Melanoma cell TRAIL resistance reversed by UVB radiation via FLIP downregulation

Meningococcal Epidemiology - New genetic lineages of Neisseria meningitides W135 continue to emerge

Mycobacterial Disease - Inhaled IFN-gamma effectively treats non-TB mycobacterial pulmonary disease

Mycobacterium Tuberculosis - Beijing/W lineage of M. tuberculosis defined on the basis of genetic markers

Myelodysplastic Syndromes - Reduced-intensity conditioned HSCT is safe/effective in myelodysplastic patients

Neocortex Genes - Genes expressed in the upper layers of the neocortex are identified

Neural Stem Cell Research - Neural SC REST/NRSF gene activation sufficient to cause neuronal differentiation

Neural Stem Cell Research - Neural SCs promote axon regrowth via cellular guidance after spinal cord injury

Norovirus Outbreak - Alterations to norovirus capsid structure explains 2002-2003 outbreaks

Personnel - Life sciences company names member to board of directors

Personnel - Valeta A. Gregg, PhD, JD, elected to bio products company board of directors

Programmed Cell Death - Apoptotic death in B- and T-lymphocytes can be quantified with a new assay

Proteomics - Proteomics used to identify markers for diagnosis of enteric pathogens

Public Health - Public health emergency response information system developed in China

Respiratory Syncytial Virus - IFN-gamma reduced in children with severe respiratory syncytial virus infection

SARS Outbreak - Different SARS epidemic curves reveal similar impacts of control measures

Salmonella Outbreak - Restaurant patrons sickened by chef infected with drug-resistant S. typhimurium

Septic Shock - A readily available marker to predict mortality in septic shock is needed

Sexually Transmitted Disease - A few HIV-infected men in Australia are still having unprotected sex

St. Louis Encephalitis Virus - Springtime drought facilitates St. Louis encephalitis virus amplification

Stem Cell - Paper published on the origin and function of skin-derived precursors

Stem Cell Research - Biotech company comments on California initiative to support stem cell research

Stem Cell Research - Chemicon International acquires mouse embryonic stem cell product lines

Stem Cell Research - Endocrinologists see hope for stem-cell use as diabetes cure

Stem Cell Research - Engineered stem cells can home in on tumors and deliver drug payload in mice

Stem Cell Research - High-affinity receptor for IgE on dendrites modified by TGF-beta1 concentration

Stem Cell Research - Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

Stem Cell Research - Mood stabilizer valproic acid stimulates forebrain SC GABA neurogenesis

Stem Cell Research - The artery wall is a source of progenitor cells that have regenerative potential

Stem Cell Transplantation - HSCT patients at moderate risk for developing supraventricular tachyarrhythmias

Stem Cell Transplantation - IL-7 does not effect immunological reconstitution after HSCT

Stem Cell Transplantation - Nonmyeloablative ASCT decreases treatment-related mortality

Stem Cell Transplantation - Survival rates following HSCT higher in pediatric than adult transplant centers

Stem Cell Transplantation - Targeted host lymphocyte depletion facilitates TCD allograft engraftment

Streptococcus Pyogenes -  S. pyogenes recovered from scarlet fever patients molecularly characterized

Synthetic Blood - Red blood cell substitute in trials with Virginia Commonwealth for U.S. Navy

Testicular Cancer - Increased PCB congeners found in blood of mothers of sons with testicular cancer

Thiotepa Conditioning Regimen - Thiotepa conditioning regimen associated with renal and hepatic toxicity

Thrombosis - Cholesterol-lowering drug may also reduce risk of blood clots

Tissue Engineering - Bone-like tissue engineered using bone marrow stem cells and silk scaffolds

Tissue Engineering - PLGA and PLGA/chitin matrices are good matrices for normal fibroblasts

Tissue Engineering - Three-dimensional polymeric scaffolds developed for soft tissue engineering

Tuberculosis - Genetic susceptibility to tuberculosis in Africans is polygenic

Tuberculosis - Serum IgE levels higher in tuberculosis patients coinfected with HIV/parasites

Tumor Suppressor Gene - Thyroid hormone receptor beta gene functions as tumor suppressor gene

Vibrio Vulnificus - Pulsed-field gel electrophoresis used to analyze Vibrio vulnificus strains

Viral Gastroenteritis - Norovirus and sapovirus infection detected in children with gastroenteritis

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