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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . December 16th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Cord Blood - IL-15 enhances cytotoxicity/receptor expression/neonatal NK cell expansion

Embryonic Development - Multiple functions of Jab1 required for early embryonic development

HLA Typing - High-resolution class I HLA typing may optimize donor selection/improve outcome

Tissue Engineering - Acellular liver matrix improves survival and function of cultured hepatocytes

Tissue Engineering - Heparin conjugated polylactide may be applied as blood compatible material

Acute Myeloid Leukemia - Dual-specificity fusion toxin selective and potent agent for AML treatment

Aldosteronism - Increased primary aldosteronism prevalence reflects increased screening tests

Animal Studies - Mice produce transgenic progeny after in vivo germ line stem cell transduction

Anthrax - Drug demonstrates survival benefits when given after anthrax exposure

Anticoagulants - Potential decrease in thromboembolism must be balanced against bleeding risk

Antimicrobials - Novel compounds have antiretroviral and antibacterial activity

Antithrombotics - Report presents strategies for implementing thrombosis management guidelines

Antithrombotics - Report provides guidelines for the use of vitamin K agonists

Apoptosis - Rituximab/alemtuzumab induce caspase-independent apoptotic pathway in CLL cells

Avian Cholera - Wetlands an unlikely reservoir for the bacteria that causes avian cholera

Biological Therapy - Autologous antitumor lymphocytes regress metastatic melanoma in cancer patients

Brucellosis & Q Fever - Brucellosis/Q fever seroprevalence determined in Central African Republic cattle

COX-2 Inhibitor - RNA-binding protein CUGBP2/COX-2-mediated PGE2 antagonistic in radiation damage

Cancer Therapy - Enzon, partner announce the filing of a new drug submission to Health Canada

Cardiology - New document outlines training and credential standards for carotid stenting

Chlamydia - Novel high-throughput assay screens antichlamydial activity

Chronic Lymphocytic Leukemia - Novel DNA cross-linking agent has potent/selective cytotoxicity in CLL B cells

Collaborations - Golden Hand Resources enters stem cell agreement with Ramot

Creutzfeldt-Jakob Disease - Survival predicted by correlates in sporadic Creutzfeldt-Jakob disease

Cytomegalovirus - Two pasteurization methods inactivate CMV in breast milk

Deep Vein Thrombosis - Pycnogenol offers protection from thrombotic events during prolonged air travel

Diabetes Risk - Asian Indians have low risk threshold for acquired diabetogenic factors

Diabetes Therapy - Data presented human embryonic stem cell based therapy for diabetes

Diagnostics - G-CSF response before leukopenia predicts infection defense in HD chemotherapy

Dialysis - Non-diphtheria corynebacterial infections reported in CAPD patients

Disease Associations - Interleukin-2 receptor antibody mitigates diabetic onset in liver recipients

Disease Associations - Tetraspanin crucial for basement membrane assembly in kidney and skin

Drug Delivery - Novel semicrystalline films developed for drug delivery applications

Drug Development - Collaboration to develop controlled-release formulations of oral anticoagulant

Drug Development - European pharmaceutical company gets E.U. approval for bone marrow disorder drug

Drug Development - Novel assay screens anti-SARS drugs

Environmental Health - Blood study inquiry planned in Tar Creek case

Erythropoiesis - Human heme exporter that is essential for erythropoiesis identified

Escherichia Coli - Toxin-producing E. coli survive in foods stored at wide temperature range

Facilities - Hemophilia Foundation of Michigan moves to new facility

Factor XII Deficiency - Factor XII deficiency does not affect hemostasis

Familial Amyloidotic Polyneuropathy - ECG outcomes were related to autonomic and motor functions, not heart functions

Finance - Biotech company reports third quarter results

Food Poisoning - Polycavernoside A causes fatal food poisoning from red alga Gracilaria edulis

Gene Expression - Ag-specific PBMC gene expression profiles do not reflect those of T-cell subsets

Genetic Disorders - Alterations in the MURR1 gene are seen in patients with Wilson disease

Genetic Disorders - Oxidative stress regulation by ATM gene required for self-renewal of HSCs

Graft-versus-Host Disease - Chronic GvHD suppresses relapse in CML and ALL but not in AML

HIV/AIDS & Leishmaniasis -  L. infantum enhances HIV-1 replication in MDMs through complex cytokine network

HIV/AIDS & Tuberculosis - Interference with endosomal sorting machinery contributes to AIDS/TB synergism

HIV/AIDS Drug Adherence - Several factors predict virologic success in antiretroviral adherence program

HIV/AIDS Epidemiology - Median CD4 lymphocyte counts are low in HIV-uninfected adults in Botswana

HIV/AIDS Healthcare - HIV-1 genotype/virtual phenotype correlate for predicting PI/NNRTI resistance

HIV/AIDS Pathogenesis - HIV-1 alone does not cause death of uninfected/latently-infected CD4 cells

HIV/AIDS Pathogenesis - Superantigen stimulation causes CD4 apoptosis in HIV-infection children on HAART

HIV/AIDS Research - CCR5 inhibitor causes transient increase in X4 virus in R5/X4-infected macaques

HIV/AIDS Research - Galantamine and nicotine inhibit HIV-1 gp120-induced microglial activation

HIV/AIDS Research - HIV-1 virion fusion assay measures virion fusion independently of uncoating

HIV/AIDS Research - RTF prevents bystander T-cell death associated with HIV infection

HIV/AIDS Research - SI viruses may hasten disease progression by perturbing T cell homeostasis

HIV/AIDS Research - Temporal HIV-1 structures detected in samples separated by 22 months or more

HIV/AIDS Treatment - HPLC method monitors atazanavir therapy in HIV-infected patients

HIV/AIDS Treatment - Mobius subfamily member kalata B1 exhibits anti-HIV activity

HIV/AIDS Treatment - Zidovudine forms DNA adducts in treated HIV-infected patients

HIV/AIDS Viral Load - Abbott LCx concordant with Roche Amplicor and Bayer bDNA HIV viral load assays

HIV/AIDS-Associated Infection - Higher CD4 counts/HAART predicts pulmonary M. kansasii/HIV infection survival

HIV/AIDS-Associated Nephropathy - HAART helps prevent progression of pediatric HIV-associated nephropathy

HIV/AIDS-Mental Health - HIV/AIDS patients beliefs vary on causal attributions of fatigue

Hair Studies - Beta-catenin/lef-1 signaling required for DP-induced hair differentiation

Heart Disease Risk - Vitamin E may help some diabetics avoid risk

Hematological Disease - Laser correlative spectroscopy assay enables early diagnosis

Hematology - Extended beta-globin locus control region elements prolong transgene expression

Hematology - Pharmacogenetics enhances the management of patients on warfarin therapy

Hematology - Techniques to evaluate erythrocyte deformability in diabetes outlined

Hematopoiesis - Activated H-Ras regulates hematopoietic cell survived by modulating Survivin

Hemophilia - OBI-1, recombinant procine Factor VIII, to enter phase II clinical studies

Hepatitis B Virus - Eisai in-licenses antihepatitis B agent clevudine

Herpesvirus Outbreak - Owner likely spreads deadly herpesvirus to colony of captive common marmosets

Hyperthyroidism - Iodine contaminants responsible for neonatal chemical hyperthyroidism in Nigeria

Immune Response - DC-T cell interactions in BM play important role in immune responses to antigens

Immunosuppression - Calcineurin inhibitors slow fibrosis progression after HCV-related liver grafts

Infection - Manufacturing agreement for staph infection treatment announced

Insulin Pump - U.S. FDA alternate site clearance helps blood glucose meter users

Ischemic Stroke - Report presents guidelines for therapeutic management of ischemic stroke

Legal Issues - Settlement to fund massive health study of water contamination

Leishmaniasis - Cutaneous leishmaniasis treated with lipid formulations of amphotericin B

Leukemia - Study: StemEx for the treatment of leukemia safe and efficacious

Leukemia - Umbilical-cord blood works well against leukemia in adults as well as children

Liver Transplantation - Short-term weight loss would expand the pool of living liver transplant donors

Lung Cancer - Long-term smokers avoid lung cancer risk if they quit smoking

Lymphoma - NK cells induce resistance to cytotoxic chemotherapy in B lymphoma cells

Malaria -  Plasmodium falciparum polymorphisms analyzed from Brazilian Amazon region

Malaria - Individual malaria disease susceptibility/outbreak severity varies in Sudan

Mutagenesis - Glycophorin A is potential biomarker for mutagenic effects of pesticides

Myoblast Transplantation - Follow-up data on myoblast cell therapy for congestive heart failure presented

Myocardial Injury - Cytochrome P450omega-hydroxylases have a role in exacerbating myocardial injury

Natural Products - beta-HIVS suppresses TNF receptor-associated protein 1 gene expression

Neural Stem Cell Research - GluR2 predominantly expressed among AMPA receptor subunits in neural SCs

Neural Stem Cell Research - Pleiotrophin signaling systems involved in modulation of fate of neural SCs

Norovirus - Detergent followed by bleach/detergent reduces Norovirus contamination

Obstetrics - Guidelines address use of antithrombotics by pregnant women

Obstetrics - Preconception anemia affects pregnancy outcome in Chinese women

Oncology - Platelet activation shifts the angiogenic balance in cancer patients

Osteoporosis - Antagonizing PPARgamma activity in fat effectively combats osteoporosis

Platelet Activation - Platelet secretion pathway mediated by cGMP-dependent protein kinase

Pneumocystis Carinii - SP-A is local effector molecule in lung host defense against P. carinii

Pneumocystis Carinii Pneumonia - Suspected pediatric PCP in resource-poor settings should be treated as emergency

Prostate Cancer - Coding sequence determined for orthologs of prostate cancer susceptibility gene

Prostate Cancer - Primary tumor-derived human prostate cancer cells retain neoplastic phenotypes

Pyomyositis - Bacterial pyomyositis increasing in HIV and non-HIV infected patients in the US

RNA Research - Electroporation improves the success of embryonic stem cell transfection

Renal Cell Carcinoma - HIF1A gene polymorphisms associated with renal cell carcinoma phenotype

Respiratory Disease - Asbestos precipitates tissue factor production in lung epithelial cells

Respiratory Syncytial Virus - Bovine respiratory syncytial virus detected/quantitated by real-time RT-PCR

Respiratory Syncytial Virus - Palivizumab used to control RSV outbreak in neonatal intensive care unit

Restructuring - Pharmaceutical company announces plan to discontinue gene editing operations

Rheumatoid Arthritis - Rheumatoid arthritis inhibited by agonistic anti-4-1BB monoclonal antibody

Robotic Surgery - Surgical robot used to remove renal artery aneurysm at Canadian health center

Selenium - Bioavailable selenium not preferentially toxic to transformed hepatocytes

Septicemia - Study shows mast cells linked to asthma and eczema can help cure sepsis in mice

Stem Cell Research - Bryostatin-1 enhances maturation/antigen-presenting ability of dendritic cells

Stem Cell Research - DNA demethylation necessary for epigenetic reprogramming of somatic cell nuclei

Stem Cell Research - Gfi-1 restricts proliferation and preserves functional integrity of HSCs

Stem Cell Research - Hematopoietic stem cells are highly receptive to adenovirus type 11p

Stem Cell Research - ID/OLIG protein interactions mediate BMP4 inhibition on OL differentiation

Stem Cell Research - Informed consent recommendations offered for tissue/cell research donors

Stem Cell Research - Poll shows support for stem cell research among those who voted to re-elect Bush

Stem Cell Research - Research: Cells derived from hESCs can be immortalized by telomerase

Stem Cell Transplantation - Alpha-erythropoietin + filgrastim improves outcome/cost balance of ASCT

Stem Cell Transplantation - Megakaryocyte engraftment follows reduced-intensity conditioning

Stem Cell Transplantation - Stem cells from donors with abnormal findings can be used for HCT

Stroke - Family history predicts young women's risk of stroke

Surgical Outcomes - Blood-reduction program benefits cardiac surgery patients

Technology - U.S. HHS rates LifeTree system for tracking nation's blood supply as exceptional

Thrombocytosis - HIV/AIDS-associated thrombocytosis is associated with severe disease

Thrombosis - First international standard for common genetic test approved by WHO

Thrombosis - High levels of anxiety may affect coagulation of blood

Tissue Engineering - Bioreactor validated for engineering vocal fold tissues

Tissue Engineering - Tissue engineered stomach regenerates into complex tissue resembling stomach

Transfusion - Report provides suggestions for blood transfusions for terminal patients

Transplant Medicine - Better methods are needed to prevent or treat rejection of lung transplants

Transplant Medicine - Positive anticardiolipin antibodies were not associated with inferior outcomes

Transplant Medicine - Researchers suggest review of Chile's approach to liver-transplant waiting lists

Transplant Medicine - Study investigates the mechanisms of organ rejection

Tuberculosis - Mathematical model predicts emergence of multidrug-resistant TB 'hot zones'

Tuberculosis - Small populations of fit MDRTB strains can out-compete low fitness strains

Vancomycin Resistance - Two vancomycin-resistant E. faecium outbreaks in NICU caused by different clones

Virology - Influenza vaccination is not associated with liver transplant rejection

Yersinia Pestis - Study shows evolution of virulent Yersinia pestis epidemic clone

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