Rheumatoid Arthritis
Rheumatoid arthritis inhibited by agonistic anti-4-1BB monoclonal antibody
Published in Blood Weekly, December 16th, 2004
According to a study from South Korea, "Collagen type II-induced arthritis is a CD4+ T-cell-dependent chronic inflammation in susceptible DBA/1 mice and represents an animal model of human rheumatoid arthritis. We found that development of this condition, and even established disease, are inhibited by an agonistic anti-4-1BB monoclonal antibody."
"Anti-4-1BB suppressed serum antibodies to collagen type II and CD4+ T-cell recall responses to collagen type II. Crosslinking of 4-1BB evoked an antigen-specific, active suppression mechanism that differed from the results of...
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Source: Blood Weekly (2004-12-16)
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