Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . December 30th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Artificial Liver Support - Extracorporeal albumin dialysis improves survival in acute liver failure
Bone Tissue Engineering - Porous alginate/hydroxyapatite scaffolds developed for bone tissue engineering
Cord Blood - Rap1 expression occurs during maturation of megakaryocytes from cord blood cells
Diagnostics - Novel method eliminates platelet error source in PBL mDNA quantification by rPCR
Embryonic Stem Cell Research - Glycogen- and albumin-producing hepatocyte-like cells generated from ESCs
Acute Lymphoblastic Leukemia - U.S. FDA committee recommends accelerated clofarabine approval for ALL
Acute Myeloid Leukemia - Real-time RT-PCR assay monitors DEK-CAN fusion transcripts in AML
Adipogenesis - Notch pathway dispensable for adipocyte specification
Antienteroviral Therapy - Novel compounds have potent antienteroviral activity
Antiretroviral Monitoring - Therapeutic drug monitoring simplified for twice-daily lopinavir/ritonavir
Apoptosis - Cannabinoid dexanabinol inhibits NF-kappa B
Apoptosis - p53-dependent replication checkpoint is defective in cancer cells
Artificial Heart - Novel motor speed controller improves AnyHeart performance
Autoimmune Hemolytic Anemia - Humanized anti-IL-6R antibody can induce long-term remission
Blood Banking - Daxor gets blood banking contract for Idant Laboratories division
Blood Physiology - Effect of prothrombin G20210A mutation on protein C activation reported
Blood Pressure - Blood pressure seems to react in 3 minutes to changes in ambient temperature
Bloodborne Pathogens - Unwise practices encourage hepatitis C transmission in Pakistan blood donors
Bone Marrow Transplantation - Monocyte counts predict optimal BM harvest time in absence of CD34 results
Bone Marrow Transplantation - Selective amplifier genes allow gene transduction without marrow conditioning
Breast Cancer - Cystatin M is a novel candidate tumor suppressor gene for breast cancer
Business Update - Golden Hand Resources changes name
Cancer Prognosis - Protein levels associated with remission, survival
Cancer Research - Avastin plus the FOLFOX4 study achieved primary endpoint of overall survival
Cancer Research - VELCADE data presented at hematology meeting
Cancer Therapy - Company files IND with U.S. FDA for T-cell clinical trials
Chemotherapy - Mathematical model predicts time to neutrophil recovery after HD chemotherapy
Collaborations - Development collaboration for Trigen's oral anticoagulant, TGN 167
Collaborations - Development deal signed for longer-acting Kogenate
Colorectal Cancer - Shikonin induces apoptosis in colorectal carcinoma cells
Dengue Virus - Infection/dissemination of Dengue virus from recent mosquito species is low
Dengue Virus - Predictive markers identified for dengue shock syndrome
Drug Addiction - Clinical trials for agent to treat methamphetamine addiction initiated
Drug Monitoring - Automated LC/LC-MS rapidly analyses samples for therapeutic drug monitoring
Embryogenesis - Hsp47 is required for molecular maturation of type IV collagen
Embryonic Stem Cell Research - DNA hypomethylation blocks ESC differentiation/induces histone hyperacetylation
Embryonic Stem Cell Research - ES cells form columnar epithelia by hensin and squamous epithelia by laminin
Embryonic Stem Cell Research - ESC-derived cardiomyocytes restore myocardial electromechanical properties
Embryonic Stem Cell Research - Temporal expression changes during differentiation of NSCs derived from ESCs
Epidemic Prediction - Occurrence of super spreading events of SARS predicted by statistical analysis
Epstein-Barr Virus - EBV LMP2A does not require palmitoylation to localize to buoyant complexes
Equine Encephalitis - Equine encephalitis virus adaptation to epizootic vectors influence spread
Escherichia Coli - Complete nucleotide sequence determined for drug resistant E. coli outbreak
Exercise & Nutrition - Diet-induced hyperphagia influenced by sex and exercise
Genomics - Novel GeneSwitch system regulates expression of sFRP-1 protein
Germ Cell Research - c-kit/SCF signaling loss increases male germ cell depletion following busulfan
HIV/AIDS Diagnostics - Life science company receives additional U.S. FDA clearance for quality controls
HIV/AIDS Immunology - HLA class II alleles not associated with HIV resistance/susceptibility
HIV/AIDS Microbicide - Mannose-specific plant lectins are microbicidal against HIV-1
HIV/AIDS Mortality - Low platelet counts linked to decreased survival in HIV-infected women
HIV/AIDS Pathogenesis - RA signaling contributes HIV latency establishment in monocytes/macrophages
HIV/AIDS Prevention - Correlates identified for recent HIV antibody testing among injection drug users
HIV/AIDS Prevention - HIV self-testing explored as a new option for HIV prevention
HIV/AIDS Prevention - Prevention intervention increases safe sex practices in HIV+ substance users
HIV/AIDS Research - Characterization of Nef-CXCR4 interactions important for apoptosis induction
HIV/AIDS Research - Endogenous RT activity is the best surrogate measure of infectious HIV-1 titer
HIV/AIDS Research - Genetic variants of APOBEC3G accelerate HIV-1 disease progression
HIV/AIDS Research - HIV-2 Gag interacts with PRP4 and inhibits phosphorylation of splicing factor 2
HIV/AIDS Research - Hsp16 inhibits HIV-1 by suppressing Vpr-specific activities
HIV/AIDS Research - Interactions between hnRNP A2 and HIV-1 A2REs influence HIV-1 gene expression
HIV/AIDS Research - Lentiviral cDNA library used to clone HIV-1-induced cell death inhibitor
HIV/AIDS Research - Majority of CSF T cells are not HIV-1 producing
HIV/AIDS Research - PFV-1 infection increases HIV-1 cell binding via Bet-independent mechanism
HIV/AIDS Research - R5 HIV-infected cells kill CD4 cells via induction of syncytia formation
HIV/AIDS Research - Reemergent R5 HIV more closely related to its predecessor than to X4 strains
HIV/AIDS Research - Unintegrated HIV-1 DNA participates in virus replication
HIV/AIDS Therapy - Anti-HIV activity characterized for resveratrol and its metabolites
HIV/AIDS Therapy - CXCR4 inhibitor AMD3100 has side effects/does not decrease HIV viral load
HIV/AIDS Therapy - Cyclic peptides used to select ScFv antibodies to HIV-1 coreceptor CCR5
HIV/AIDS Therapy - HIV-1 protease inhibitors block TLR2 and TLR4-induced NF-kappa B activation
HIV/AIDS Therapy - Indinavir impairs protein synthesis and phosphorylations of MAPKs in myocytes
HIV/AIDS Therapy - Mega-HAART causes rapid HIV decay in HAART-experienced children
HIV/AIDS Therapy - New class of NNRTIs are highly microbicidal against HIV-1
HIV/AIDS Therapy - Not all antiretroviral medications cross the blood-testis barrier
HIV/AIDS Therapy - Risk of virologic failure with LPV/r increased in children pretreated with PIs
HIV/AIDS-Associated Lipodystrophy - Interleukin-18 linked to HIV-associated lipodystrophy
HIV/AIDS-Related Cognition - Cognitive impairment increases with progression to AIDS
HIV/AIDS-Related Dyslipidemia - Protease inhibitors increase 10-year risk for coronary heart disease
HIV/AIDS-Related Infection - Fine-needle aspiration cytology in TBL differs between HIV+ and HIV- patients
HIV/AIDS-Related Kaposi Sarcoma - Injection drug use not associated with increased risk of AIDS-related KS
HIV/AIDS-Related Wasting - Growth hormone improves muscle oxygen utilization during exercise in HIV wasting
Hearing Loss - Utility of rheopheresis in sudden hearing loss reviewed
Hematology - A Jak2-based cell growth switch selects genetically modified erythroid cells
Hematology - Multiplex real-time quantitative RT-PCR screens donor blood for pathogens
Hematology - Pre-eclampsia-inducing macromolecule increases microvascular permeability
Hematology - Preterm infants lack heparin-dependent platelet-activating antibodies
Hematology - The pleiotropic effects of erythropoietin warrant more analysis
Hematology - Uniparental isodisomy defines the origins of an afibrogenemia proband
Hematopoiesis - Interferon alpha treatment of bone marrow stroma inhibits hematopoiesis
Hepatitis C Virus - Experimental nonpharmacological treatment promising in reducing viral load
Hypertension - Diminished L-arginine bioavailability in hypertension revealed
Hypertension - Paracellular chloride permeability is regulated by WNK4 kinase
Hypohydration - Study examined how hypohydration alters thermoregulatory responses in the heat
Intestinal Cancer - Epiregulin deficiency does not alter intestinal cancer susceptibility
Ischemic Preconditioning - Protection of ischemic preconditioning is mediated by endogenous peptide
Kaposi Sarcoma-Associated Herpesvirus - Defective KSHV is present in KS tumors and primary effusion lymphoma cells
Kaposi Sarcoma-Associated Herpesvirus - KSHV latent nuclear antigen disruption leads to abortive episome persistence
Kidney Disease - RNA targeting Fas protects mice from renal ischemia-reperfusion injury
Leukemia - Farnesyl transferase inhibitor can help patients at high risk for developing AML
Leukemia - Half of relapsed CLL patients respond to two biologics with chemotherapy
Leukemia - Haploidentical killer cells may provide hope for some patients with AML
Leukemia - Peptide vaccine can produce complete remission in myeloid leukemia patients
Listeria Monocytogenes - L. monocytogenes isolates form distinct but overlapping populations
Lovastatin - Lovastatin attenuates CD40-mediated inhibition of Abeta microglial phagocytosis
Malaria - Construction sites yield elusive malaria vector
Mergers & Acquisitions - Amended merger agreement reached by biotechnology companies
Methicillin Resistance - Cost-savings achieved by vigorous eradication of epidemic MRSA from hospital
Multiple Myeloma - Caveolin-1 is the molecular target of the proteasome inhibitor bortezomib
Multiple Myeloma - U.S. FDA accepts sNDA filing with priority review for VELCADE for myeloma
Mutagenesis - New splice site mutations in the WAS gene cause Wiskott-Aldrich syndrome
Mycobacteria - Novel mycobacterium isolated from patients with febrile syndrome
Neural Stem Cell Research - Cultured neural stem cells promote functional recovery following focal ischemia
Obesity - Relationship between risk knowledge and obesity different for men and women
Obstetrics - rhEPO is safer therapy for anemia in pregnant patients with hemoglobinopathy
Oncology - A new fusion gene construct strengthens the efforts of lymphoma chemotherapy
Personnel - Blood substitute developer names chief medical officer
Personnel - California-based blood products supplier taps Erik Halstrom for VP
Physiology - Plasma volume shift during exercise analyzed, link to blood volume revealed
Product Licensing - U.S. FDA changes classification of semi-automated whole blood separation system
Quality of Life - Clinical sequelae affect quality of life in HIV-infected patients
Quality of Life - Measurement of quality of life increasingly important in HIV disease
Quality of Life - Symptom management improves quality of life in HIV infected patients
Renal Disease - Natural killer cell activity unaffected by ozonated autohemotherapy
Rheumatoid Arthritis - Premature stem cell aging provides basis for immune-mediated tissue damage in RA
SARS - ACE1 polymorphism may influence progression of pneumonia in SARS
Sickle Cell Disease - Federal health agency halts sickle cell study after subjects suffer strokes
Sickle Cell Disease - NHLBI stops sickle cell anemia transfusion study
Skin Cancer - p53 point mutation at Ser389 increases sensitivity to UV radiation
Stem Cell Research - Amnion mesenchyme cells express phenotypes of neuroglial progenitor cells
Stem Cell Research - Androgen receptor expressed in several cell types in skeletal muscle
Stem Cell Research - Chondrogenic differentiation from ESCs enhanced via modified culture conditions
Stem Cell Research - Creating $3 billion stem cell agency no small feat
Stem Cell Research - Distinct cell "side population" has high drug efflux capacity in tumor cells
Stem Cell Research - Downstream genes of ascidian muscle determinant gene Ci-macho1 identified
Stem Cell Research - Lentiviral vectors funnel genes into neural stem cells for therapeutic use
Stem Cell Research - MKK4 and MKK7 required for full activation of JNK by toxic metal exposure
Stem Cell Research - Study data show hESC-derived oligodendrocytes remyelinate in vivo
Stem Cell Research - TGF-beta increases alpha-actin/decreases gelsolin to promote MSC differentiation
Stem Cell Research - Tel/Etv6 is essential and selective regulator of adult HSC survival
Stem-Cell Transplantation - Hemostatic parameters can predict poor outcome
Survival and Mortality - VEGF-A expression is a prognostic marker for angioimmunoblastic T-cell lymphoma
Thalidomide - Thalidomide associated with adverse effects in patients with neoplastic diseases
Thrombosis - Prevalence of hereditary thrombophilic factors in portal vein thrombosis studied
Tissue Engineering - Electrospun poly-l-lacticle nanofiber scaffolds ideal for cartilage repair
Tissue Engineering - Novel method improves biocompatibility of PGA for tissue engineering
Tissue Engineering - PEG-genipin hydrogels provide scaffolding for tissue engineering applications
Tranplant Medicine - Researchers set new standard of care for adult cord blood transplant patients
Transfusion Medicine - Immune complex-induced PMN activation underlies TRALI
Transfusion Medicine - Paper: RhAG plays key role in maintaining pH balance in red blood cells
Transplant Medicine - Certican MRP expanded to include 10 new E.U. member states
Trichomonas Infection - Cysteine proteinase 39 may play role during Trichomonas vaginalisinfection
Varicella Zoster Virus Infection - Severe abdominal pain is important sign of VZV infection in SCT recipients
Vector Development - Lipophosphoramides offer a safe alternative to viral gene vectors
Virology - Hepatitis C virus E2 protein interacts with CD81 to alter lymphocyte migration
Virology - Lentiviral transduction of cord SCs yields high-level beta-globin expression
Weight Loss - Potential weight loss and vision benefits found in eggs
Wound Management - Dermacyn Wound Care receives CE Mark
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