Transfusion Medicine

Paper: RhAG plays key role in maintaining pH balance in red blood cells

Published in Blood Weekly, December 30th, 2004

A paper published by a team from the French Institute of Health and Medical Research in Paris, France, provides insight into the functional role of Rhesus proteins, clinically significant to the process of matching donor blood types to transfusion recipients.

Dr. Jean-Pierre Cartron and his colleagues, including Jackson Laboratory researcher Connie Birkenmeier who provided Cartron's team with mouse models of hemolytic anemia, showed that ammonia undergoes facilitated movement across the red blood cell membrane rather than movement by simple diffusion as previously thought. They have identified a critical role for the Rhesus-associated glycoprotein (RhAG) in this...

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Source: Blood Weekly (2004-12-30)

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