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Rap1 expression occurs during maturation of megakaryocytes from cord blood cells

Published in Blood Weekly, December 30th, 2004

Rap1 expression occurs during maturation of megakaryocytes from cord blood cells.

According to a study from Italy, "The expression of the small GTPase Rap1 in human megakaryocytes (MKs) differentiated from cord blood (CB)-derived progenitors was investigated.

"High levels of Rap1 were detected in the majority of mature megakaryocytes independently of days of culture, while a very low percentage of immature megakaryocytes was found to express a small amount of the protein. Rap1 was predominantly detected on internal alpha-granule but not on the plasma membrane."

"By contrast," said A. Balduini and colleagues, "CD41 was clearly...

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