Published in Blood Weekly, December 30th, 2004
According to a study from Italy, "The expression of the small GTPase Rap1 in human megakaryocytes (MKs) differentiated from cord blood (CB)-derived progenitors was investigated.
"High levels of Rap1 were detected in the majority of mature megakaryocytes independently of days of culture, while a very low percentage of immature megakaryocytes was found to express a small amount of the protein. Rap1 was predominantly detected on internal alpha-granule but not on the plasma membrane."
"By contrast," said A. Balduini and colleagues, "CD41 was clearly...
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