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Hematology

Preterm infants lack heparin-dependent platelet-activating antibodies

Published in Blood Weekly, December 30th, 2004

Preterm infants may not produce significant levels of heparin-dependent platelet-activating antibodies.

"Heparin is frequently used in preterm infants to prolong the patency of intravascular catheters," according to physicians in Chicago, who conducted a study "to evaluate the prevalence of heparin-dependent platelet-activating antibodies in newborns."

"A cross-section of all preterm newborn infants expected to require heparin to maintain patency of a central venous access line were enrolled," explained P. Kumar and colleagues at Northwestern Memorial Hospital. "A blood sample was obtained soon after birth before heparin exposure to exclude the...

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