Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . January 13th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Genetic Testing - Rapid prenatal diagnosis by QF-PCR detects major numerical chromosome disorders
Stem Cell Research - SC expressing homing receptors expanded from cryopreserved/unselected cord blood
Stem Cell Transplantation - IL-8 may play important role during engraftment after hematopoietic SCT
Stem Cell Transplantation - Routine high resolution HLA-A/B/C typing does not improve HSCT outcome
Tissue Engineering - Novel tissue scaffolds developed for craniofacial and joint defects
Acute Myelogenous Leukemia - Farnesyl transferase inhibitor can help patients at high-risk for AML
Acute Myeloid Leukemia - ATRA improves CR rate/event-free & overall survival in elderly patients with AML
Allergy and Immunology - Biological loading of allergens different due to local influences
Alzheimer Disease - Dihydrolipoamide dehydrogenase gene associated with Alzheimer disease
Anemia - Baseline hematocrit was a predictor of mortality rate in anemic heart patients
Anemia - Findings from study of anemia treatments published
Antigen Receptors - Bam32 B cell adaptor molecule regulates B cell antigen receptor internalization
Apoptosis - Alpha-DL-tocopherol protects ESFT cells from betulinic acid-induced apoptosis
Apoptosis - Antioxidant prevention of apoptosis not just associated with scavenging ability
Apoptosis - NF-kappa B activity determines sensitivity of kidney cells to apoptosis
Argatroban - Argatroban reduced thrombin generation regardless of antithrombin levels
Arrhythmia - Animal studies show stem cells might make biological pacemaker
Avian Sarcoma Virus - ASV integration sites in human genome distributed over all chromosomes
Blood Drive - Rutland County, Vermont, sets record during blood drive
Blood Substitute - Detroit clinics to test blood substitute as part of nationwide test
Bone Marrow Disorders - Discovery of genetic profiles, mutations aid treatment of bone marrow disorders
Breast Cancer - Hexadecylphosphocholine causes rapid cell death in mammary tumor cells
Calcivirus Infection - Histological features of calcivirus infection overlap with allograft rejection
Cancer Therapy - Company acquires c-myb antisense drug from Temple University
Cancer Therapy - Pharma company announces positive clinical results for PBI-1402
Carcinogens - Different genotoxic mechanisms for lung cells exposed to chromate particles
Cardiology - Low frequency magnetic fields turn on stem cell cardiogenesis
Cardioprotection - Mechanistic data can help in developing therapeutics for acute cardioprotection
Chemotherapy - University researchers find method to boost immune system after chemo in mice
Cirrhosis - Essex researchers discover clues to liver disease
Clinical Trial - Immunology company provides clinical trials update
Coagulation Therapy - Circular aptamers targeting thrombin show enhanced capabilities
Coagulation Therapy - Novel reaction scheme promising for anticoagulative glass substrate development
Colorectal Cancer - DNA test for colorectal cancer yields disappointing results
Congestive Heart Failure - Phase 2 clinical study of thyroid hormone drug in heart failure initiated
Coxiella Burnetii - Overall C. burnetii growth cycle characteristic of a closed bacterial system
Crimean-Congo Hemorrhagic Fever - MRNA segment of Crimean-Congo hemorrhagic fever virus outbreak strains analyzed
Dengue Fever - Human leukocyte antigen DQ1 positively associated with dengue fever
Diabetes - Health Department says diabetes is rising as a cause of death in New York
Diabetes Detection - Beam of light can find signs of diabetes
Disease Prevention - Early diagnosis and prevention of renal and cardiovascular disease essential
Drug Development - Cells expressing artificial complementary peptide inhibit HIV-1 infection
Drug Development - Hinnuliquinone inhibits HIV-1 protease
Drug Development - Mitochondrial membrane potential disruptor compounds attenuate Lv1 activity
Drug Development - Novel anti-HIV drug design strategy combats susceptibility to drug resistance
Drug Development - Novel targets identified for HIV-1 treatment
Drug Development - Thermodynamics elucidated for next-generation protease inhibitor TMC114
Embryogenesis - Hypoxia enhances hemangioblast specification during early development
Embryonic Stem Cell Research - ESC-derived mouse macrophages is an improved model to study vascular disease
End-Stage Organ Disease - Management of pregnancy in transplant recipients reviewed
Endocrine - Thalassemia treatment results in excessive iron deposits in almost all tissues
Epstein-Barr Virus - TRAF3 is important in EBV-encoded oncoprotein LMP1-mediated signaling
Escherichia Coli - Novel protein ensures timely initiation of E. coli chromosome replication
Essential Thrombocythemia - Pregnancy complications reduced with low-dose aspirin, platelet-lowering drugs
Finance - Dialysis-products company refinances senior credit facilities
Flavenoids - Natural flavones more potent CYP19 inhibitors than flavanones
Gaucher Disease - Altered glucocerebrosidase may contribute parkinsonism risk in Gaucher Disease
Gene Polymorphisms - MAO-A gene polymorphisms associated with panic attacks and GAD
Glioblastoma - MXI1-0 is overexpressed in glioblastomas
Graft-versus-Host Disease - Target antigens determine graft-versus-host disease phenotype
HIV/AIDS Cognition - Interrater reliability modest for neurocognitive diagnoses in HIV infection
HIV/AIDS Drug Screening - Novel method screens HIV-1 RT inhibitors based on based on dock-MM-PB/GS
HIV/AIDS Pathogenesis - APOBEC3G exploits RNA packaging to infiltrate HIV-1 particles
HIV/AIDS Pathogenesis - Amino-terminal region of HIV-1 nucleocapsid required for APOBEC3G packaging
HIV/AIDS Pathogenesis - Close relationship between HIV-1 phenotypic changes and HIV pathogenesis
HIV/AIDS Research - AA insertions near gag cleavage sites restore activity of mutant protease
HIV/AIDS Research - Alpha-defensins inhibit/augment HIV replication by mechanisms that precede RT
HIV/AIDS Research - CD4 phosphorylation partially reverses Nef down-regulation of CD4
HIV/AIDS Research - Chloroquine prevents HIV-1 Tat from perturbing the cytokine balance
HIV/AIDS Research - Complete gene sequencing revealed novel IFN regulatory factor-1 polymorphisms
HIV/AIDS Research - Cross-species transmission of SIV realized
HIV/AIDS Research - Early plasmacytoid DC changes predict viral load rebound in primary infection
HIV/AIDS Research - Functionally impaired HIV CD8 cells show high affinity TCR-ligand interactions
HIV/AIDS Research - Gag influences HIV-1 species-specific tropism
HIV/AIDS Research - HIV-1 Vpr and Sp1 interplay modulates p21(WAF1) gene expression in astrocytes
HIV/AIDS Research - P-glycoprotein expression/genotype correlates with HIV-1 CXCR4 expression
HIV/AIDS Research - SIV Vif proteins are not effective inhibitors of human APOBEC3G or APOBEC3F
HIV/AIDS Research - Selection for cellular Ref1 activity loss releases HIV-1 from CypA dependence
HIV/AIDS Research - Ts1 infection of astrocytes accelerates cell death
HIV/AIDS Research - Viral/cellular protein interactions cause selective uptake of host ICAM-1 by HIV
HIV/AIDS Therapy - C-min/IC50 ratio predicts antiviral response during initial amprenavir-treatment
HIV/AIDS Therapy - Monomeric forms of peptide T analogs have conformational heterogeneity
HIV/AIDS Therapy - Statins reduce HIV-1 replication by preventing ICAM-1 and LFA-1 interactions
HIV/AIDS Vertical Transmission - HIV-1-infected breast milk cells associated with risk of vertical transmission
HIV/AIDS-Associated Dementia - Brain dopaminergic transporters decreased in HIV-associated dementia
HIV/AIDS-Related Fertility - Medically assisted fertility is ethically acceptable in HIV-positive persons
HIV/AIDS-Related Psychosis - Atypical antipsychotic use associated with higher persistence in HIV infection
HIV/AIDS-Related Virology - Certain CTL epitopes subject to repeated positive selection in HIV infection
Hantavirus - Captive breed colonies of wild rodents are hantavirus-free
Hantavirus - Nested RT-PCR detects hantavirus in hantavirus cardiopulmonary syndrome patients
Herpesvirus - HHV-8 can actively replicate in PBMCs
Infection - Identification of laminin receptor as a dengue virus serotype 1 receptor
Influenza A Pandemic - Genetic origins of 1918 flu pandemic different from 1957/1968 strains
Lead Hazard - Michigan Governor signs bills intended to protect children against lead
Leukemia - Chemotherapy lowers levels of antioxidants and micronutrients
Leukemia - Company presents safety and efficacy results of phase I/II StemEx study
Leukemia - Researchers discover a stem-cell switch lurking within leukemias
Malaria - Plasmodium falciparum development is promoted by recurrent fever
Myocardial Infarction - Human blood stem cells transform themselves to repair injured animal hearts
Neurospora - Novel gene regulates purine catabolism in Neurospora crassa
Obesity Research - Caloric restriction mimetics include lipid-activated nuclear receptor agonists
Osteogenesis Imperfecta - Stem cells transplanted to female fetus
Patents - Court finds in ViaCell's favor in patent case
Potable Water - Safe potable water provisions vary among hospitals caring for immunocompromised
Protein Signalling - PIR-B negatively regulates neutrophil and macrophage integrin signaling
Renal Function - G-CSF accelerates regeneration/prevents renal tubular epithelial cell apoptosis
Reperfusion - Role of mannose-binding lectin-pathway during reperfusion injury studied
Respiratory Syncytial Virus - Cytoplasmic RSV replication induces nuclear heat shock response
SARS-Related Thrombosis - Increased incidence of thrombotic complications in SARS
Salicylates - Salicylates inhibit NFAT-dependent transcription
Salmonella - Nosocomial S. enteriditis outbreak associated with lyophilized enteral nutrition
Sickle Cell Anemia - Positive results reported from ICA-17043 phase II trial in sickle cell anemia
Stem Cell Research - Crry gene involved in LFA-1 dependent proliferation of thymocytes
Stem Cell Research - Engineered muscle-derived SCs have potential as muscular dystrophy treatment
Stem Cell Research - Gene expression of erythroid progenitors profiled by micro-serial analysis
Stem Cell Research - IL-1alpha suppresses cartilage matrix protein expression via BMP-2 suppression
Stem Cell Research - Neural stem cells can become cells that form vascular tube structures
Stem Cell Research - Two-step culture method generates functional DCs from cord blood CD34+ cells
Stem Cell Research - Use of endogenous stem cells for degenerative brain disorders is challenging
Stem Cell Transplantation - Purified NK-cell infusion consolidates engraftment after haploidentical SCT
Stem Cells Research - Differentiated neural stem cells potential source for cell replacement therapy
Tissue Engineering - New strategies use SCs/bioresorbable delivery for cartilage/bone regeneration
Tissue Engineering - Runx2 brings mineralization to myoblast scaffolds designed to treat bone
Tissue Regeneration - Bone marrow cells participate in striated muscle tissue regeneration
Transfusion Medicine - New data support an indirect link between hepatitis C and thyroid cancer
Transfusion Medicine - Red blood cell boost could overcome blood shortages
Transfusion Medicine - Virucidal gamma irradiation doesn't disrupt IVIG integrity
Transfusion Technology - Care Fusion announces FDA 510k clearance for wBloodCare
Transgenics - Real-time qPCR determines transgene copy number in transgenic animals
Transplant Medicine - Hepatitis B viremia before liver transplantation guides post-surgical therapy
Transplantation Medicine - Company receives FDA priority review designation for PULMINIQ NDA
Tuberculosis - Novel anti-tuberculosis agents with potent sterilizing activity are needed
Vector Development - Adeno-associated virus gene vectors may treat hemophilia B
West Nile Virus - WNV VLPs are valuable tool to investigate tissue tropism in early infection
West Nile Virus - West Nile virus encephalitis an emerging disease in renal transplant recipients
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