Carcinogens
Different genotoxic mechanisms for lung cells exposed to chromate particles
Published in Blood Weekly, January 13th, 2005
"Hexavalent chromium [Cr(VI)] is a well-established human lung carcinogen. Water solubility has proven to be a key factor in the carcinogenicity of Cr(VI), with the water insoluble or 'particulate' compounds the more potent carcinogens. Pathology studies indicate that chromates target cells at bronchial bifurcation sites in human lungs.
"However, it is uncertain what roles particle internalization and dissolution play in the genotoxicity of these compounds to human lung cells. We investigated these mechanisms in a human lung cell line after exposure to...
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Source: Blood Weekly (2005-01-13)
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