Alzheimer Disease
Dihydrolipoamide dehydrogenase gene associated with Alzheimer disease
Published in Blood Weekly, January 13th, 2005
disease.
According to a study from the United States, "Abundant biochemical evidence links deficient activity of mitochondrial a-ketoglutarate dehydrogenase with neuropathologically confirmed Alzheimer's disease (AD). Reduced a-ketoglutarate dehydrogenase activity has also been associated with anti-mortem measures of clinical disability.
"One of the genes encoding this complex, namely, DLD, lies within a chromosome 7 region that is in linkage disequilibrium with AD. We therefore examined the hypothesis that variation in DLD is associated with AD risk."
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Source: Blood Weekly (2005-01-13)
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