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Endothelial Progenitor Cells

Hierarchy of EPCs is based on clonogenic and proliferative potential

Published in Blood Weekly, January 20th, 2005

Researchers have identified a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.

According to published research from the United States, "Emerging evidence to support the use of endothelial progenitor cells (EPCs) for angiogenic therapies or as biomarkers to assess cardiovascular disease risk and progression is compelling. However, there is no uniform definition of an EPC, which makes interpretation of these studies difficult. Although hallmarks of stem and progenitor cells are their ability to proliferate and to give rise to functional progeny, EPCs are primarily defined by the expression of cell-surface antigens."

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