Adult T-Cell Leukemia
Adult T-cell leukemia cells down-regulate CD26 antigens via epigenetic machinery
Published in Blood Weekly, January 27th, 2005
According to published research from Japan, "CD26/dipeptidyl peptidase IV (DPPIV), a T-cell-activation antigen, is a 110-kD type II surface glycoprotein expressed on various types of normal cells. CD26/DPPIV is considered a multifunction housekeeping protein. Malignant cells often show altered CD26/DPPIV expression or no CD26/DPPIV expression, thus suggesting a useful marker for assessing some T-cell malignancies.
"In this study, cell surface protein and messenger RNA expression profiles for CD26/DPPIV were examined in 49 patients with adult T-cell leukemia (ATL), 10...
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Source: Blood Weekly (2005-01-27)
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