Bone Marrow Transplantation
Genetic polymorphisms predict outcome of bone marrow transplants
Published in Blood Weekly, February 3rd, 2005
According to a recently published review from England, "Analysis of non-histocompatibility leucocyte antigen (HLA) functional genomics, together with conventional risk factors in haematopoietic stem cell transplantation (HSCT) can lead to predicting outcome in HLA-matched sibling transplant recipients."
"Polymorphisms of cytokine genes including tumor necrosis factor alpha, interleukin-10, interferon gamma and interleukin (IL)-6, associate with more severe acute graft-versus-host disease (aGvHD). Donor genotype for IL-1 receptor antagonist (IL-1Ra) has been associated with reduced...
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Source: Blood Weekly (2005-02-03)
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