Allergy & Immunology

LIR3 counter-regulatory for both adaptive and innate receptors

Published in Blood Weekly, February 3rd, 2005

Leukocyte immunoglobulin-like receptor 3 is counter-regulatory for both adaptive and innate receptors.

"Basophils, recruited from the blood to tissues, have been implicated by their presence in diverse allergic disorders including bronchial asthma, allergic rhinitis, and cutaneous contact hypersensitivity.

"We hypothesized that like other leukocytes involved in inflammatory responses, basophils would express members of the leukocyte immunoglobulin-like receptor (LIR) family of immunoregulatory molecules on their cell surface," researchers in the United States report.

"We identified LIR7, an activating member coupled to the common...

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Source: Blood Weekly (2005-02-03)

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