Stem Cell Transplantation

T-cell-depleted megadose SCT from mismatched donor viable option for adults

Published in Blood Weekly, February 10th, 2005

T-cell-depleted megadose stem cell transplantation from a mismatched family donor is a viable option for adults with acute high-risk leukemia.

According to investigators in Italy, "Since 75% of patients with high-risk acute leukemia do not have a human leukocyte antigen (HLA)-identical sibling, alternative sources for hematopoietic stem cell transplantation (HSCT) are matched unrelated donors (MUD), unrelated umbilical cord blood (UD-UCB) and one HLA haplotype mismatched family members (haploidentical).

"The chance of finding a suitable donor in the international voluntary donor registries is limited by frequency of the HLA phenotype and the time...

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Source: Blood Weekly (2005-02-10)

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