HIV/AIDS Therapy
Arylsulfonamides inhibit wild-type and mutant HIV-1 protease
Published in Blood Weekly, February 10th, 2005
"The arylsulfonamide derivatives described herein were such potent inhibitors of human immunodeficiency virus type 1 (HIV-1) protease (enzyme, E) that values for the inhibition constants (Ki ) could not be determined by conventional steady-state kinetic techniques (i.e., the minimal enzyme concentration usable for the activity assay was much greater than the value of the dissociation constant).
"Consequently, two alternative methods were developed for estimation of Ki values. The first method employed kinetic determinations of values for k1 ), and...
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Source: Blood Weekly (2005-02-10)
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