HIV/AIDS Therapy
Polyarginine inhibits gp160 processing by furin and suppresses HIV-1 infection
Published in Blood Weekly, February 10th, 2005
According to published research from the United States, "Correct endoproteolytic maturation of gp160 is essential for the infectivity of human immunodeficiency virus type 1. This processing of human immunodeficiency virus-1 envelope protein, gp160, into gp120 and gp41 has been attributed to the activity of the cellular subtilisin-like proprotein convertase furin.
"The prototypic furin recognition cleavage site is Arg-X-Arg/Lys-Arg. Arg-Arg-Arg-Arg- Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin....
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Source: Blood Weekly (2005-02-10)
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