Anticoagulants

Oral anticoagulants may induce CV calcifications as an adverse side effect

Published in Blood Weekly, February 10th, 2005

Oral anticoagulant treatment: friend or foe in cardiovascular disease'

According to recent research from Netherlands, "Calcification is a common complication in cardiovascular disease and may affect both arteries and heart valves. Matrix gamma-carboxyglutamic acid (Gla) protein (MGP) is a potent inhibitor of vascular calcification, the activity of which is regulated by vitamin K. In animal models, vitamin K antagonists (oral anticoagulants [OACs]) were shown to induce arterial calcification."

L.J. Schurgers and colleagues of the University of Maastricht explained, "To investigate whether long-term OAC treatment may induce calcification in humans...

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Source: Blood Weekly (2005-02-10)

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