Osteoarthritis
Chondrocytes express chemokine eotaxin-1
Published in Blood Weekly, February 24th, 2005
"The expression of the chemokine, eotaxin-1, and its receptors in normal and osteoarthritic human chondrocytes was examined, and its role in cartilage degradation was elucidated in this study.
"Results indicated that plasma concentrations of eotaxin-1 as well as the chemokines, RANTES, and MCP-1alpha, were higher in patients with osteoarthritis (OA) than those in normal humans," scientists in Taiwan report.
"Stimulation of chondrocytes with IL-1beta or TNF-alpha significantly induced eotaxin-l expression. The production of eotaxin-1 induced expression of its own receptor of CCR3 and...
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Source: Blood Weekly (2005-02-24)
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