Cord Blood Cell Research
Higher temperature increases megakaryopoiesis in cord blood cell cultures
Published in Blood Weekly, February 24th, 2005
"Based on previous evidence suggesting positive effects of fever on in vivo hematopoiesis, we tested the effect of hyperthermia on megakaryopoiesis (MK) in ex vivo cultures of CD34-enriched cord blood (CB) cells," wrote investigators in Canada.
"The cells were cultured at 37 degreesC or 39 degreesC for 14 days in cytokine conditions optimized for megakaryocyte development and analyzed periodically.
"Compared to 37 degreesC," C. Prouix and colleagues reported, "the cultures maintained at 39 degreesC produced significantly more (up to 10-fold) total cells,...
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Source: Blood Weekly (2005-02-24)
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