Acute Myeloid Leukemia
MNK1 is target of several leukemogenic fusion proteins
Published in Blood Weekly, February 24th, 2005
In a recent study from Germany, "[m]icroarray analyses were performed to identify target genes that are shared by the acute myeloid leukemia (AML) translocation products PML-RARalpha, PLZF-RARalpha and AML1-ETO in inducibly transfected U937 cell lines."
"The cytoplasmic serine and threonine kinase MNK1 was identified as one of the target genes," reported J. Worch and coauthors at the University of Munster. "At the protein level, MNK1 was significantly induced by each of the three fusion proteins."
"Protein half-life analyses showed that PML-RARalpha enhanced MNK1...
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Source: Blood Weekly (2005-02-24)
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