Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . March 3rd, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Biomedical Engineering - Biological constructs developed for tissue engineering
Blood Substitute - Blood substitute does not influence coagulation at relevant concentrations
Hemodilution - Albumin-heme improves circulatory volume following hemorrhage
Liver Transplantation - Artificial liver support improves cardiac function in pretransplant patients
Stem Cell Research - Round cells potential source of donor cells to improve muscle regeneration
Acute Myeloid Leukemia - B-cell translocation gene 1 biomaker monitors acute myeloid leukemia remission
Acute Myeloid Leukemia - XPD genetic variation predicts treatment outcome and AML risk after chemotherapy
Antithrombin - Native and de-N-glycosylated antithrombin studied, molecular mass deduced
Balantidium Coli Infection - Balantidium coli causes enteric lesions in pigs infected with circovirus
Biotechnology - Stromelysin-2 enhances keratinocyte migration for wound repair
Bioterrorism - Delayed hematological complications occurs following mustard gas exposure
Breast Cancer - Breast carcinoma cell line is resistant to DNA-damaging drugs
Breast Cancer - Common variant of CASP8 gene associated with reduced risk of breast cancer
Breast Cancer - Truck driver occupation linked to increased BRCA1/2 male breast cancer mutation
Business Update - Cell-therapy provider claims newspaper ran misleading article
Business Update - Clinical Data gets rights to distribute hematology analyzers and reagents
Business Update - Instrumentation developer to enter joint development agreement with Wescor
Cancer Genetics - SLIT2 and SLIT3 genes frequently methylated in gliomas and colorectal cancers
Cancer Risk - Larger babies have higher risk of certain cancers in adulthood
Chernobyl Cancer Risk - Statistically significant cancer increase in most contaminated Chernobyl region
Chlamydia Pneumoniae - Levofloxacin does not eliminate C. pneumoniae from infected macrophages
Chronic Inflammatory Disease - Phenolic antioxidants inhibit VCAM-1 in chronic inflammatory diseases
Collaborations - Research and development collaboration to generate stable cell line announced
Colon Cancer Risk - ALOX and COX polymorphisms influence colon cancer risk in Caucasians
Congestive Heart Failure - Pennsylvania medical center implants fluid monitoring device for heart failure
Cutaneous Malignant Melanoma Risk Factors - Inverse association between vitamin A and cutaneous malignant melanoma risk
Diagnostics - Findings advance knowledge in diagnostics research
Diagnostics - Researchers develop infectious disease diagnostic tool
Dialysis - Amplatz thrombectomy device suitable for declotting dialysis access grafts
Dialysis - Hepatotoxicity of PVC plasticizers TOTM and DEHP determined
Dioagnostics - qRT-PCR used to predict CMV disease and monitor onset of pre-emptive therapy
Drug Development - Company announces new indication, CLL, for GCS-100LE clinical trial program
Embryogenesis - Chk-1 gene is required for S-M checkpoint during early embryogenesis
Embryonic Germ Cell Research - Embryonic germ cells were derived from fetal gonads and cultured
Embryonic Stem Cell Research - ESC-derived progenitors with RG characteristics generate neurons in spinal cord
Embryonic Stem Cell Research - GATA6-/laminin-dependent mechanisms regulate endodermal/ectodermal ESC fates
Embryonic Stem Cell Research - Signaling molecules direct differentiation of ESCs into dorsal interneurons
End Stage Renal Disease - Technology company receives U.S. NSF grant to develop blood-compatible catheters
Epidemiology - HTLV-1 significantly associated with lymphoid malignancies in Dominica
Epstein-Barr Virus - Epstein-Barr virus pathogenesis may depend on length of HIV infection
Epstein-Barr Virus - Lytic cycle gene regulation of Epstein-Barr virus analyzed
Finance - Blood-processing company reports positive third-quarter results
Finance - Chemokine/cytokine-focused company announces exercise of over-allotment option
Finance - Clinical information systems provider announces financial results
Finance - Cord Partners' parent company commences trading
Finance - Drug developer announces acceleration of employee stock option vesting
Finance - Immunotherapy company announces increased 2004 revenue despite Q4 dip
Gastroenterology - Association between H. pylori and reflux disease varies with region
Genetics and Genomics - Techniques for isolating RNA from blood samples compared
HIV/AIDS Drug Monitoring - Genotypic inhibitory quotient predictive of virological response to SQV/RTV
HIV/AIDS Pathogenesis - A-catenin links HIV-1 CCR5 and CXCR4 co-receptors to the cytoskeleton
HIV/AIDS Pathogenesis - Fitness costs limit viral escape from CTLs at structurally constrained epitope
HIV/AIDS Pathogenesis - Incubation period of acute retroviral syndrome is a multistep process
HIV/AIDS Pathogenesis - Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by RT
HIV/AIDS Research - Constrained "molecular tongs" designed to dissociate HIV-1 protease dimer
HIV/AIDS Research - HIV-1 Nef produces survival signals through Erk-mediated Bcl-X-L induction
HIV/AIDS Research - HIV-1-RT Gln145Met/leu change confer drug resistance/impair virus replication
HIV/AIDS Research - Parallel tempering method predicts HIV accessory protein structure
HIV/AIDS Research - Researchers' findings advance HIV/AIDS research
HIV/AIDS Research - Researchers' work adds to HIV/AIDS body of knowledge
HIV/AIDS Research - SIV-HIV chimera expressing HIV-1-RT used to study evolution of viral resistance
HIV/AIDS Therapy - Lovastatin potentiates antitumor effects of saquinavir against lymphoma cells
HIV/AIDS Therapy - New findings in HIV/AIDS therapy described
HIV/AIDS Therapy - New findings in the area of HIV/AIDS therapy described
HIV/AIDS Therapy - New findings in the area of HIV/AIDS therapy detailed
HIV/AIDS Therapy - Next-generation NNRTI active against NNRTI-resistant HIV-1
HIV/AIDS Therapy - PAF antagonist with anti-HIV-1 activity crosses blood-brain barrier
HIV/AIDS Transmission - Coreceptor-independent HIV transfer induced by contacts between CD4 cells
HIV/AIDS Treatment - Metabolic abnormalities less with atazanavir than with other protease inhibitors
HIV/AIDS-Related Tuberculosis - AIDS-related mycobacterial reactivation may result from T-cell immunity loss
Hantavirus Pulmonary Syndrome - 3 genotypes associated with hantavirus pulmonary syndrome circulating in Yuto
Helicobacter Pylori - H. pylori-induced spermine oxidation results in apoptosis and DNA damage
Hematology - Antivirals treat hemophiliacs who acquired hepatitis C through blood products
Hematology - Lamivudine-induced mutants may link hepatitis B to acute myeloid leukemia
Hematology - Oncoretroviral-mediated factor VIII gene therapy corrects hemophilia
Hematology - SPLI linked to regulated proteolysis after platelet activation
Hematopoiesis - MII-dependent Hox program drives hematopoietic progenitor expansion
Hemostasis - Plasma thrombomodulin studied, profibrinolytic effect revealed
Hepatoblastoma - Conductin is a direct target gene of WNT signaling hepatoblastomas
Immunology - Role of CD40 signaling in germinal center development clarified
Immuontherapy - Grouper/mullet iridovirus bears genetic and antigenic similarities to RSIV
Kallikrein - Plasma kallikrein studied, inhibition by Cl-inhibitor documented
Kaposi Sarcoma-Associated Herpesvirus - Cidofovir used to provide insight into KSHV replication and pathogenesis
Klebsiella Pneumoniae - K. pneumoniae outbreak produces new carbapenern hydrolyzing beta-lactamase
Leukemia - Drug fights pre-leukemia condition in two ways
Leukemia - TYK2 appears to be a key regulator of the surveillance of B lymphoid tumors
Listeria Monocytogenes - L. monocytogenes sigma(B) needed for stress-response induction in GI passage
Malaria - Malaria is a multi-faceted disorder
Melanoma - Findings advance knowledge in melanoma research
Mergers & Acquisitions - Heart assist device company to acquire MedQest Products, Inc.
Multiple Myeloma - Companies advance PXD101 into phase II clinical program
Neural Stem Cell Research - Cell-line derived from neural crest has characteristics of melanocyte precursors
Neuroprotection - Echinacoside rescues neuroblastoma cells from TNF alpha-induced apoptosis
Neuroscience - Valproic acid suppresses disease progression in ALS model
Obstetrics - Most antenatal coagulation screening is unnecessary
Oncology - Taxol induces caspase-10-dependent apoptosis
Oncology - VEGF is a target for the management of multiple myeloma
Parkinson Disease - Foundation boosts research in Parkinson and awards nearly $1 million in funding
Pediatric Oncology - BRAF gene hotspot mutations not associated with pediatric solid neoplasms
Personnel - Genome-based antibiotics developer names Thomas R. Parr chief scientific officer
Pharmaceutical Research - Pharma company reports on drug development for tsunami survivors
Phosphorylation - Kappa kinase beta species studied, serine phosphorylation demonstrated
Physiology - Ctr2 vacuolar copper transporter studied, copper mobilization observed
Platelet Aggregation - p38 MAP kinase pathway studied, role in platelet aggregation clarified
Platelets - Comparison of platelet deposition on various stents reported
Platelets - GTPase Rap2B studied, activation in agonist-stimulated human platelets revealed
Primary Anti-Phospholipid Syndrome - Impaired endothelial function more prominent in arterial vs. venous involvement
Prostate Cancer - New agents being developed for prostate cancer prevention
Prostate Cancer - Prostate tumor progression may reflect aberrant DNA repair
Prostate Cancer - Researchers describe findings in prostate cancer studies
Renal Insufficiency - Company announces physician-sponsored study of Benephit Infusion System
Ross River Disease - Spatial-temporal analysis identifies Ross River virus disease outbreaks
SARS Coronavirus - SARS outbreak demonstrates vulnerability of liver transplantation service
Septic Shock - Using bosentan during the later stages of septic shock: a promising strategy
Sex Steroids - Sex steroids reduce DNasel accessibility of androgen receptor promoter in brain
Simian Immunodeficiency Virus - SIV cell tropism in culture is not predictive of in vivo tropism or pathogenesis
Stem Cell - Therapeutics company announces fast track designation for stem cell product
Stem Cell Research - Competitive repopulation assay monitors stem cell progeny after transplantation
Stem Cell Research - Differential gene expression characterized in stroma of giant cell bone tumor
Stem Cell Research - Id4 regulates neural progenitor proliferation and differentiation
Stem Cell Research - Immortalized otocyst cell lines study early stages of inner ear development
Stem Cell Research - MSCs from different sources differentiate into functional hepatocyte-like cells
Stem Cell Research - Rapid elimination of MCs by apoptosis does not lead to significant inflammation
Stem Cell Research - Retroviral transduction augments the selection of modified stem cells
Stem Cell Research - SOX9 gene is key regulator of cartilage link protein
Stem Cell Research - Sarcoglycan expression impaired after HSCs engraft into cardiac/skeletal muscle
Stem Cell Research - Studies advance knowledge in stem cell research
Stem Cell Research - Wnt 3a promotes proliferation and suppresses osteogenic differentiation of MSCs
Stem Cell Research - Writ signaling elicits multiple functions in stem cells
Stem Cell Therapy - Inhibitory NK cell receptor-expressing T cells with CTL activity expanded
Stem Cell Transplantation - qPCR to monitor adenovirus after transplant useful for fatal disease prevention
Stem Cells Research - BM-derived SC fused with striated muscle not sufficient to activate muscle genes
Surgical Technology - Biomaterials/biosurgical company receives AATB accreditation
Thyroid Microcarcinoma - BRAF(T1796A) transversion prevalent mutational event in thyroid microcarcinoma
Transfusion Medicine - Doctors need to prepare for blood shortages now
Transfusion Medicine - Fewer transfusions after study publication
Transplant Medicine - Cytokine genotypes place renal allograft patients at risk for graft rejection
Transplant Medicine - Immunology company announces bone marrow transplant trial
Transplant Medicine - Long term data on implant rejection is hopeful for kidney transplant patients
Transplant Medicine - Michigan groups launch organ donation improvement program
Transplant Medicine - New stem cell source could boost bone marrow success
Tumor Suppression - TRAIL inhibits tumor growth but is nontoxic to hepatocytes
Umbilical Cord Blood Transplantation - Cord blood transplant/reduced regimen after ASCT is promising MM treatment
Venous Thromboembolism - Long-term anticoagulation is effective in patients with venous thromboembolism
Virology - Retroviral vectors prefer distinct sites for genomic integration
West Nile Virus - License application submitted for West Nile Virus assay for blood screening
Wilms Tumor - Beta-catenin target gene in WT1-mutant Wilms tumor identified
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