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Stem Cell Research

Round cells potential source of donor cells to improve muscle regeneration

Published in Blood Weekly, March 3rd, 2005

Round cells are a potential source of donor cells to improve muscle regeneration.

"Recent studies have demonstrated that a distinct subpopulation with stem cell-like characteristics in myoblast culture is responsible for new muscle fiber formation after intramuscular transplantation. The identification and isolation of stem-like cells would have significant implications for successful myogenic cell transfer therapy in human muscle disorders.

"Using a clonal culture system for mouse muscle satellite cells, we have identified two cell types, designated 'round cells' and 'thick cells', in clones derived from single muscle satellite cells that have been...

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