Stem Cell Research
Phosphophoryn regulates MSC gene expression via integrin/MAPK signaling pathway
Published in Blood Weekly, March 10th, 2005
"Extracellular matrix proteins (ECMs) serve as both a structural support for cells and a dynamic biochemical network that directs cellular activities. ECM proteins such as those of the SIBLING family (small integrin-binding ligand glycoprotein) could possess inherent growth factor activity.
"In this study, we demonstrate that exon 5 of dentin matrix protein 3 (phosphophoryn (PP)), a non-collagenous dentin ECM protein and SIBLING protein family member, up-regulates osteoblast marker genes in primary human adult mesenchymal stem cells (hMSCs), a mouse...
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Source: Blood Weekly (2005-03-10)
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