HIV/AIDS Pathogenesis
HIV-1 can dysregulate CD4+ T cells that express CXCR4
Published in Blood Weekly, March 10th, 2005
CXCR4-tropic HIV-1 Env functions as a viral chemokine in unstimulated CD4+ cells.
"Interaction of HIV-1 envelope glycoprotein gp120 with the chemokine receptor CXCR4 triggers not only viral entry but also an array of signal transduction cascades. Whether gp120 induces an incomplete or aberrant set of signals, or whether it can function as a full CXCR4 agonist, remains unclear.
"We report that, in unstimulated human primary CD4+ T cells, the spectrum of signaling responses induced by gp120 through CXCR4 paralleled that induced by the natural ligand stromal cell-derived factor...
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Source: Blood Weekly (2005-03-10)
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