HIV/AIDS Pathogenesis
CD27 expression promotes long-term survival of CD8+ cells in HIV-infection
Published in Blood Weekly, March 17th, 2005
"Human immunodeficiency virus (HIV)-specific CD8+ T cells persist in high frequency in HIV-infected patients despite impaired CD4+ T helper response to the virus but, unlike other differentiated effector cytotoxic T lymphocytes, most continue to express the tumor necrosis factor receptor family member CD27.
"Because the ligand for CD27 (CD70) is also overexpressed in HIV-infected hosts, we examined the nature of expression and consequences of CD27 expression on HIV-specific CD8- T cells," researchers in Switzerland report.
"Analysis of CD27- and CD27- T...
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Source: Blood Weekly (2005-03-17)
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