HIV/AIDS Therapy
Nelfinavir induces adipocyte necrosis by oxidative stress
Published in Blood Weekly, March 17th, 2005
"Protease inhibitor treatment strongly diminishes mortality in HIV-infected patients. This treatment has also been associated with lipodystrophy and has been shown to alter adipocyte differentiation.
"The protease inhibitor nelfinavir has been indirectly implicated in the appearance and development of lipodystrophic syndrome, as well as in adipocyte cell death," scientists writing in the Journal of Acquired Immune Deficiency Syndromes report.
"The aim of this study was to evaluate the effects of nelfinavir on the 3T3-F442A adipocyte cell line. Nelfinavir (30 mcM)...
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Source: Blood Weekly (2005-03-17)
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