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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . March 24th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - Rehydrated RBCs sufficiently deformable for normal microcirculation transit

Blood Safety - NAT testing finds hepatitis B in a blood donor with unapparent acute infection

Bone Marrow Transplantation - Distinct recovery phases of innate cellular-mediated immunity after BMT

Bone Marrow Transplantation - Flow cytometry/microbead platform evaluates immune reconstitution after BMT

Tissue Engineering - Organoid culture in elliptic hollow fibers develops hybrid artificial liver

Aspergillosis - EIA/qPCR used to diagnose invasive aspergillosis in high-risk patients

Bacterial Evolution - VNTRs appropriate evolutionary marker for studying bacterial transmission events

Biomedical Engineering - Sonic hedgehog gene enhanced tissue engineering stimulates bone formation

Blood Safety - 54-year-old woman dies after receiving wrong blood

Blood Safety - Patients accidentally infected with hepatitis C respond well to interferon

Blood Substitute - Enrollment complete in phase 2 clinical trial of hemoglobin-based oxygen carrier

HIV/AIDS Research - Findings advance knowledge in HIV/AIDS research

Business Update - Company announces entry into field of regenerative medicine

Business Update - Sentigen Holding Corp. Announces the Sale of Its Specialty Media Division

Cancer Therapy - Evotec OAI to provide process validation for phase III compound, AMD 3100

Cancer Therapy - Findings advance knowledge in cancer therapy research

Cardiac Cell Therapy - Review details clinical potential of stem cell sources for cardiac cell therapy

Cardiology - Tryptase is proangiogenic in the healing heart

Chronic Hepatitis C - Liver regeneration does not affect HCV recurrence after split liver transplant

Collaborations - Company signs research agreement with Detroit hospital to target ER care

Colon Cancer - Nondegraded total RNA extracted from colonocytes from normal/malignant tissue

Cryptococcus Diagnostics - RT-PCR assay detects and quantitates Cryptococcus neoformans

Drug Development - Modified heparin antagonizes angiogenesis without affecting coagulation

Drug Development - P3 and P4 moieties analyzed, novel binding of factor VIIa inhibitor revealed

Embryonic Research - Failure to degrade poly(ADP-ribose) causes early embryonic lethality

Enterotoxigenic Escherichia Coli - Phenotypes determined for ETEC associated with early childhood diarrhea

Escherichia Coli 0157 Diagnostics - IS1203 PCR rapidly genotypes Shiga toxin-producing Escherichia coli O157

Finance - Developer, manufacturer of human cell lines reports 2004 results

Finance - HIF-focused company completes equity financing

Finance - Maker of ultrasound-enhanced microcatheters raises $18M in series B financing

Finance - Pharmaceutical company hires banking firm to identify partners, investors

Gastroenterology - Cathepsin B blockade stops reperfusion-induced liver damage in steatotic livers

Gene Expression - Interleukin regulation of gene expression studied, role of adherence shown

HIV/AIDS Coinfection -  Schistosoma mansoni/HIV-1 coinfection leads to CD4 cell reduction

HIV/AIDS Coinfection - CD4 counts higher in HIV-positive patients infected with Helicobacter pylori

HIV/AIDS Diagnostics - Real-time PCR rapidly discriminates between HIV-2 genotypes A and B

HIV/AIDS Drug Side Effects - Mitochondrial pathogenesis in AIDS due to NRTI-induced DNA polymerase inhibition

HIV/AIDS Encephalitis - Increased FKBP12 may explain vulnerability of basal ganglia to HIV infection

HIV/AIDS Mental Health - Substance P has role in pathophysiology of stress/depression in HIV infection

HIV/AIDS Neurology - CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

HIV/AIDS Pathogenesis - Acute SIV brain infection leads to upregulation of IL6 ad IFN-regulated genes

HIV/AIDS Pathogenesis - Amyloid precursor protein may facilitate monocyte entry into brain

HIV/AIDS Pathogenesis - Conformational flexibility retained in HIV-1 Rev-RNA complexes

HIV/AIDS Pathogenesis - HIV-specific CTLs from long-term survivors select a unique T cell receptor

HIV/AIDS Pathogenesis - LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase

HIV/AIDS Pathogenesis - MCP-1-2578G allele associated with elevated MCP-1 in cerebrospinal fluid

HIV/AIDS Pathogenesis - Macrophage-secreted MMP 9 is down-regulated following HIV-1 infection

HIV/AIDS Pathogenesis - Soluble toll-like receptor 2 associated with progression of HIV infection

HIV/AIDS Pathogenesis - Ubiquitinated histone H1B is a cofactor to HIV-1 resistance factor

HIV/AIDS Pathogenesis - Urokinase plasminogen activator receptor important in HIV-associated dementia

HIV/AIDS Pediatrics - HAART should be initiated in symptomatic children aged 12 months or older

HIV/AIDS Prevention - Fear of test result and stigmatization are barriers to HIV testing in Bali

HIV/AIDS Research - Data advance knowledge in HIV/AIDS research

HIV/AIDS Research - Tissue culture model analyzes macrophage activation in the brain

HIV/AIDS Therapy - Antiretroviral enfuvirtide is not an inhibitor of p450 cytochrome

HIV/AIDS Therapy - Enfuvirtide improves health-related quality of life in HIV-infected patients

HIV/AIDS Therapy - HAART adherence is the most relevant factor for virological success

HIV/AIDS Therapy - HPLC/UV method suitable for pharmacokinetics of abacavir in plasma

HIV/AIDS Therapy - Molecular basis determined for GLUT4 inhibition by protease inhibitors

HIV/AIDS Therapy - Protease inhibitors impair glucose-stimulated insulin secretion from beta cells

HIV/AIDS Therapy - Studies add new findings to HIV/AIDS therapy body of knowledge

HIV/AIDS-Associated Dementia - Antibody markers identified in HIV-associated dementia

HIV/AIDS-Associated Dementia - Blood-brain barrier compromise has role in pathogenesis of HIV-related dementia

HIV/AIDS-Associated Dementia - HIV dementia risk is associated with apolipoprotein E4 in older persons

HIV/AIDS-Associated Dementia - Oxidative stress markers increased in actively progressive HIV dementia

HIV/AIDS-Associated Infection - Severe respiratory disease necessitating hospitalization decreased in HAART era

HIV/AIDS-Related Dementia - Brain water diffusion contributes to cognitive deficits in HIV infection

HIV/AIDS-Related Dementia - CD14+ macrophage hybrid phenotype circulates in persons with high HIV viral load

HIV/AIDS-Related Dementia - HIV dementia is an evolving disease

HIV/AIDS-Related Lipodystrophy - F-18-fluorodeoxyglucose PET visualizes lipodystrophy in HIV-infected patients

Hematology - Cells secrete interleukin-1 alpha after intramarrow gene transfer

Hematology - Immature dendritic cells help CD40 ligand regress established myeloma

Hematology - Myelofibrosis with myeloid metaplasia formation and VEGF levels often parallel

Hematology - New findings in the area of hematology described

Hematology - Zebrafish model transferrin receptor 1 function in erythroid cells

Hematopoiesis - C/EBPalpha is essential for granulocyte development/regulates HSC activity

Hematopoiesis - Enhanced self-renewal of HSC mediated by polycomb gene product Bmi-1

Hematopoiesis - NF-kappaB prevents apoptosis at multiple steps of hematopoiesis by removing ROS

Hemodialysis - Access monitoring does not improve outcome

Information Technology - Technology company releases donor management system for review

Interleukins - Normal platelets possess the soluble form of IL-6 receptor

Ischemia/Reperfusion - Study investigated effects of sildenatil citrate on ischemia reperfusion injury

Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed

Leishmaniasis - Promising visceral leishmaniasis treatments must translate into actual therapy

Leptospirosis - Percutaneous exposure results in laboratory-acquired leptospirosis

Licensing - Pharmaceutical firm acquires license to endothelinB agonists for chemo delivery

Liver Transplantation - Adult living donor liver grafts offer a viable option to transplant candidates

Malaria - Malaria morbidity in children increases as transmission intensity decreases

Malaria - Malaria still reduced in areas after withdrawal of deltamethrin spray

Malaria Diagnostics - Four plasmodium species detected in blood by real-time PCR

Medical Devices - Self-calibrating nanoliter viscometers developed

Mergers & Acquisitions - Chemicon International acquires assets of Specialty Media

Metamorphosis - Red blood cells studied, low-temperature transcriptional arrest clarified

Microbial Identification - Multispacer typing useful for strain genotyping during outbreaks/bioterrorism

Microbial Resistance - Beta-lactam susceptibilities evaluated against Enterobacteriaceae isolates

Microbial Resistance - In France, ESBL-producing S. enterica strains emerging in chickens & humans

Mosquito-Borne Disease - Aircraft is the main vessel for mosquito entry into New Zealand

Mycobacterial Infection - New mycobacaterial species found in sputum of patient with hemoptoic pneumonia

Mycobacterium Abscessus - Inability to type M. abscessus by PFGE assoc. with single clone of organism

Mycobacterium Xenopi Infection -  Mycobacterium xenopi infection developed following heart transplantation

Myeloma - "Smart" immune cells kill more cancer

Myocardial Infarction - Matrix-embedded marrow cells generate new vessels in ischemic hearts

Natural Products - San-Huang-Xie-Xin-Tang studied, effect on hypotension and inflammation shown

Neuroscience - Transduced adult neural stem cells thrive after inner ear transplantation

Personnel - Biotechnology company appoints president of the board

Personnel - Stem cell technology company appoints new non-executive cochairman

Plasma Collection - Haemonetics inks supply contract for plasma collection products

Platelets - Sildenafil studied, effect on human platelet secretory function clarified

Prenatal Genetic Diagnosis - Alternative screening protocol for blood diseases in pregnancy described

Pseudomonas Aeruginosa -  Pseudomonas aeruginosa is non-clonal but has an epidemic population

Retroviral Infection - Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML

Reverse Transcriptase - AZT 5'-triphosphate mimics inhibit HIV reverse transcriptase

SARS Coronavirus - Chronological evolution of Ab levels determined after SARS coronavirus infection

SARS Coronavirus - RT-PCR distinguishes SARS coronavirus from other respiratory tract infections

Sickle Cell Disease - Enrollment initiated for phase III trial of ICA-17043 in sickle cell disease

Space Travel - Nanobacterial infections important during space travel

Stem Cell Research - CD38 expressed in myeloblast nuclei during RA-induced differentiation

Stem Cell Research - CTGF regulated by Wnt and BMP signaling in MSC osteoblast differentiation

Stem Cell Research - Cultured tooth papilla cells induce hair follicle regeneration and fiber growth

Stem Cell Research - Follicular epithelium and skin epidermis originates from the amnion

Stem Cell Research - Gene-corrected stem cells can help patients with cystic fibrosis

Stem Cell Research - MSCs isolated from BM and fetal liver can form a hematopoietic microenvironment

Stem Cell Research - Not all leukemic oncogenes transform committed SCs lacking self-renewal capacity

Stem Cell Research - PTH/PTHrP signaling is major regulator of bone marrow ontogeny

Stem Cell Research - Steroid hormones control differentiation of ESCs into various cell types

Stem Cell Transplantation - Alternate hemibody irradiation + HD chemotherapy treats hematological malignancy

Stem Cell Transplantation - Five-year survival >80% after HSCT with matched unrelated donors

Stem Cell Transplantation - Reconstitution of CMV-specific CD8+ T cells delayed after SCT

Stem Cells - Study finds hematopoietic stem cells depend on a single protein Mcl-1

Streptococcal Equi Diagnostics - Multiplex PCR differentiates closely related streptococcal species

Stroke - Drug helps bleeding stroke patients

Tick-Borne Virus - Tick-borne viruses in Europe are potential agents of bioterrorism

Transplant Medicine - Diabetes increases mortality in HCV-infected patients awaiting renal transplant

Transplant Medicine - New findings in transplant medicine described

Tuberculosis -  M. tuberculosis lineage with low IS6110 copy numbers clonally expanded

Tuberculosis - Genotypic/phenotypic heterogeneity among M. tuberculosis isolates determined

Umbilical Cord Blood Transplantation - CBT treats case of EBV-related lymphoproliferative disease

Urea Cycle Disorder - Pharmaceutical company obtains FDA approval of treatment for urea cycle disorder

Vancomycin-Resistant Enterococcus - Esp/vancomycin resistance may contribute to clonal enterococcal dissemination

Vibrio Cholerae - Possible source of V. cholerae outbreak is effluent from ships or poachers

Virology - Research add new data to virology body of knowledge

West Nile Virus - West Nile virus is an emerging arbovirus

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