Stem Cell Research
CD38 expressed in myeloblast nuclei during RA-induced differentiation
Published in Blood Weekly, March 24th, 2005
"The cell surface antigen, CD38, is a 45-kDa transmembrane protein which is predominantly expressed on hematopoietic cells during differentiation," researchers in Canada explained. "As a bifunctional ectoenzyme, it catalyzes the synthesis of cyclic ADP-ribose (cADPR) from NAD+ and hydrolysis of either NAD+ or cADPR to ADP-ribose."
"All-trans-retinoic acid (RA) is a potent and specific inducer of CD38 in myeloid cells," noted L. Yalcintepe and colleagues at the British Columbia Cancer Agency. In a recent study, they found...
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Source: Blood Weekly (2005-03-24)
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