Hematology
Zebrafish model transferrin receptor 1 function in erythroid cells
Published in Blood Weekly, March 24th, 2005
"Iron is a crucial metal for normal development, being required for the production of heme, which is incorporated into cytochromes and hemoglobin. The zebrafish chianti (cia) mutant manifests a hypochromic, microcytic anemia after the onset of embryonic circulation, indicative of a perturbation in red blood cell hemoglobin production," scientists writing in the journal Development report.
"We show that cia encodes transferrin receptor 1a (tfr1a), which is specifically expressed in the developing blood and requisite only for iron uptake in erythroid precursors," stated R.A....
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Source: Blood Weekly (2005-03-24)
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