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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . April 7th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Bioartificial Liver - Bioreactor developed that supports bioartificial liver

Embryonic Stem Cell Research - Repository stores embryonic stem cell lines with genetic disorders

Stem Cell Transplantation - Chronic GVHD risk increased in patients with HLA class I mismatched donors

Stem Cell Transplantation - High plasmacytoid dendritic cell recovery improves overall survival after ASCT

Tissue Engineering - Hyaluronan gels useful for tissue engineering of aortic heart valves

Acinetobacter Infection - Risk factors identified for multidrug-resistant A. baumannii infection

Acute Myeloid Leukemia - Ceplene receives orphan drug designation in Europe for AML

Air Monitoring - PCR method quantifies A. fumigatus conidia from environmental air samples

Allergy and Immunology - Eosinophils in human blood stimulate angiogenesis

Amyloidosis - Medicare expands coverage for stem cell transplantation

Anemia - Positive data for phase I study of anemia treatment announced

Oncology - Research in oncology provides new insights

Angiology - Biodegradable implants containing factor XIII stimulate vessel growth in rats

Antimicrobial Resistance - Carbapenem resistance is emerging in strains worldwide

Avian Influenza - Cross-impact analysis predicts mutation trends in influenza A

Bioartificial Liver - Collagen/chitosan/heparin improves hepatic tissue engineering biocompatibility

Biomedical Engineering - Collagen films support osteoblast activity and bone formation

Bone Marrow Research - Bone marrow cells engraft within epidermis and proliferate without cell fusion

Bone Marrow Transplant - Monitoring of TCR-Vbeta complexity may help predict prognosis of GVHD after BMT

Business & Finance - Biopharma company announces financial results

Business Update - Contract signed for leukocyte reduction filters

Cancer Therapy - Dose optimization enables rapamycin to suppress tumor angiogenesis

Cardiovascular Research - Platelet inhibitor demonstrates consistent inhibition of platelet aggregation

Cholera Monitoring - Monitoring environment and cholera presence predicts diarrhea epidemics

Chronic Liver Disease - Patients with bleeding disorders can safely undergo transjugular liver biopsy

Coagulation Therapy - Protein C anticoagulant activity examined, role of cholesterol revealed

Coagulation Therapy - Study finds self-testing a reliable alternative to laboratory INR monitoring

Collaborations - Long-term contract signed for plasma products

Cowpox - Cowpox virus infection associated with streptococcal septicemia

Crimean-Congo Hemorrhagic Fever - ELISA method used to diagnose Crimean-Congo hemorrhagic fever

Cystic Fibrosis - Persistent environmental reservoirs of P. aeruginosa not found in CF center

Deep Vein Thrombosis - First patient recruited in ThromboView phase II North American clinical trials

Dengue Hemorrhagic Fever - Dengue hemorrhagic fever increasing among children in northern Brazil

Diabetes Type 1 - Diabetes type 1 outbreak earlier in immigrants' children born in Italy

Diagnostics - Studies add new findings to diagnostics body of knowledge

Diarrheal Illness - Hygiene interventions identified to reduce diarrhea in less developed countries

Drug Development - Company exercises option for rights to blood platelet modification technology

Drug Development - Hematide demonstrates ability to stimulate production of red blood cells

Embryonic Stem Cell Research - Cell-surface marker found on embryonic hepatoblasts

Embryonic Stem Cell Research - Embryonic stem cell differentiation evaluated in different culture conditions

Embryonic Stem Cell Research - Enforced PU.1 expression rescues osteoclastogenesis from ESCs lacking Tal-1

Embryonic Stem Cell Research - Stably transfected ESC clones maintain self-renewal and pluripotency

Environmental Health - Northern American maternal blood monitoring program established

Exercise and Nutrition - Exercise and diet have roles in prevention of chronic disease

Finance - Newborn stem-cell bank reports record growth in revenue

Finance - Stem cell-focused biotech company announces Q4, year end 2004 financial results

Food Contamination - Continuous education assures good food hygiene on merchant ships

Gallbladder Cancer - Early gallbladder cancer showed no interference with liver transplantation

Genetics & Genomics - IS1- or IS10- activated AcrEF efflux pump may relay AcrAB in serovar Typhimurium

Genomic Expression - Cytokine allele frequencies differ between racial and ethnic groups

HIV/AIDS Drug Development - Anti-HIV-1 compounds separated via capillary zone electrophoresis

HIV/AIDS Drug Development - PNA-transportan conjugate targeted to HIV-1 TAR is antiviral and virucidal

HIV/AIDS Drug Development - Plant extracts have anti-HIV activity

HIV/AIDS Drug Discovery - HIV-1 integrase inhibitors identified using 3D pharmacophore-guided database

HIV/AIDS Drug Resistance - Drug-resistant HIV-1 genotypes detected only in subjects infected after 2000

HIV/AIDS Drug Resistance - HIV-1 Vif changes associated with development of protease inhibitor resistance

HIV/AIDS Infection - Amphotericin-B reactivates latent HIV-1 infection

HIV/AIDS Lipodystrophy - VLDL elevation in early HAART therapy caused by impaired VLDL clearance

HIV/AIDS MALT Lymphoma - HIV+ MALT lymphoma remission induced by HAART alone

HIV/AIDS Pathogenesis - APOBEC3G polymorphisms not associated with HIV disease progression

HIV/AIDS Pathogenesis - C-terminal domain of HIV-1 integrase is a DNA-binding domain

HIV/AIDS Pathogenesis - Cytoplasmic tail slows HIV-1 Env folding from late prebundle into 6-helix bundle

HIV/AIDS Pathogenesis - Late stage R5 HIV-1 infection induces cytokine and CCR5 expression

HIV/AIDS Pathogenesis - M-tropic HIV-1 activation increases virus load in intestinal mucosa

HIV/AIDS Pathogenesis - Separate HIV Nef domains are required to affect MHC-1 and CD4 cells

HIV/AIDS Pathogenesis - Vpr enhances RANKL production via glucocorticoid receptor activity potentiation

HIV/AIDS Prevention - Appropriate HIV education maximizes acceptance of antenatal HIV antibody test

HIV/AIDS Prognosis - Survival prognostic factors differ by CD4 count among IVDU pre/post HAART era

HIV/AIDS Research - CD4+ cell response differs between HIV-exposed seronegative and HIV+ women

HIV/AIDS Research - MLV RNase H primer grip is an important determinant of fidelity of DNA synthesis

HIV/AIDS Research - Tat methylation by PRMT6 regulates HIV-1 gene expression

HIV/AIDS Screening - Urgent care center-based routine HIV screening programs are effective

HIV/AIDS Therapy - 20 mg/kg of amprenavir twice daily is safe for HIV-infected children

HIV/AIDS Therapy - C/EBP alpha reverses anti-adipogenic effects of nelfinavir

HIV/AIDS Therapy - Fixed conformation nucleoside analogs inhibit excision-proficient HIV-1 RT

HIV/AIDS Therapy - HAART leads to normalization of anti-Hsp70 and anti-cholesterol Ab levels

HIV/AIDS Therapy - IL-16 levels increase after structured intermittent HAART interruption

HIV/AIDS Therapy - Researchers' work adds to HIV/AIDS therapy body of knowledge

HIV/AIDS Therapy - Ritonavir does not inhibit calpain

HIV/AIDS-Associated Lipodystrophy - Subcutaneous fat loss not due to accelerated apoptosis in HIV lipodystrophy

Hematology - Angiogenic cytokines predict multiple myeloma progression

Hematology - Estrogen receptor gene expression deviates in human blood mononuclear cells

Hematology - Hemophilia A patients carry newly discovered missense FVIII gene mutations

Hematopoiesis - Recent findings in hematopoiesis provide new insights

Hemoglobin H Disease - Study tests efficiency of prenatal diagnostic tests for Hb Constant Spring

Henoch-Schonlein Purpura - Plasmapheresis can quickly resolve cerebral vasculitis in HSP patients

Human Papillomavirus - HPV-13 polymorphisms determined for HIV+ and women at risk for HIV infection

Immunology - TIM-3 gene polymorphism associated with atopic disease susceptibility

Immunosuppression - Mycophenolate mofetil delays hepatitis C recurrence after liver transplantation

Immunotherapy - Addition of GS doesn't enhance proapoptotic properties of MTX

Infection Control - Emerging Infections Program reduces response time to foodborne disease

Kaposi Sarcoma-Associated Herpesvirus - New findings in the area of kaposi sarcoma-associated herpesvirus described

Kidney Transplantation - Immunosuppressives reduce production of TNF alpha in NHBD kidneys

Legal Issues - Dialysis provider announces receipt of DOJ subpoena

Lymphoma - Epstein-Barr virus protein crucial to its role in blood cancers

Lymphoma - Investigation of CD3+/HLA-DR+ activated T cells may aid prognostics

Medical Devices - Study shows CYPHER stent associated with fewer blood clots at stent site

Multiple Sclerosis - Research suggests possible blood test for MS

Neural Embryonic Stem Cell Research - Neuronal differentiation achieved from cultured embryonic germ cells

Neural Stem Cell Research - Antibody microarray correlates cell phenotype with surface marker

Neural Stem Cell Research - Ginsenoside-Rd from Panax notoginseng enhances NSC astrocyte differentiation

Neural Stem Cell Research - NSCs from ESCs relieve symptomatic motor behavior in Parkinson disease model

Neural Stem Cell Research - RB & RB2/p130 genes have overlapping functions during early NSC differentiation

Neural Stem Cell Research - Repeated cytokine administration improves generation of dendritic cells

Neuroscience - Marrow stromal cells aid axonal regeneration after spinal cord injury

Norovirus - New data illuminates research in norovirus

Obstetrics - Tobacco smoke exposure increases resistance of umbilical blood flow

Oncology - New data illuminates research in oncology

Patents - Re-examination of two more PharmaStem cord blood stem cell patents requested

Patents - Stem cell instruments patent filed with U.S. patent office

Pathogenic Escherichia coli -  E. coli O157:H7 survival on vegetables dependent on soil compost type

Personnel - Molecular biotechnology company names Tom Muenzberg COO

Personnel - Synthetic blood-focused biopharm company convenes medical advisory board

Physiology - Lipopeptide and peptidoglycan recognition studied, role of TLR6 clarified

Platelet Preparation - Rapid, one-step density gradient centrifugation method doesn't cause activation

Pneumocystis Infection - Neonatal lungs lack maturation factors for efficient cellular functioning

Pregnancy-Associated Malaria - IL-10+ T-cell upkeep in utero may affect APC function, infant's immune response

Product Licensing - Chemicon licenses Quantum Dot antibody reagent line

Recurrent Pregnancy Loss - Thrombophilia is a common cause of recurrent miscarriage syndrome

Respiratory Pathogen - Respiratory infection spread during air travel rarely occurs

SARS - Convalescent plasma therapy shortens hospitalization stays of SARS patients

SARS - Events reconstructed during SARS outbreak in February 2003 in Singapore

SARS - Nursing students more stressed than medical students during SARS outbreak

SARS - SARS seroprevalence rate is low in apparently healthy healthcare workers

SARS Coronavirus - Recombinant nucleocapsid protein-based assay detects anti-SARS-CoV IgG

SARS Prevention - Residents of Taiwan have increased "willingness to pay" to reduce SARS risk

Sepsis - Researchers report new pro-inflammatory role for anti-inflammatory enzyme

Sepsis - Risk of death from bloodstream infection greater in less severely ill

Sepsis - Study identified sepsis-induced changes in signal transduction pathways

Sporotrichosis - Sporotrichosis diagnosis may be confounded by Leishmania coinfection

Stem Cell Research - 4-Hydroxynonenal inhibits cell proliferation in fetal liver HSCs

Stem Cell Research - Bcl-2 reduced/Fas activated by SCF/KIT inhibition signaling in melanocyte SCs

Stem Cell Research - Cytokines reverse gamma-globin gene silencing in erythroid stem cells

Stem Cell Research - First derivation of human embryonic stem cells without exposure to cell feeders

Stem Cell Research - HSC homing is optimal when CXCR4 is incorporated in membrane lipid rafts

Stem Cell Research - Negative feedback loop controls SCF-KIT signaling pathway

Stem Cell Research - PBMCs and BM-derived HPC populations affected by acute soman poisoning

Stem Cell Research - Prominin-1/CD133 is expressed certain types of kidney cancer

Stem Cell Transplantation - Selected cytokine elimination does not alter allogeneic hematopoietic resistance

Stem-Cell Transplantation - Novel real-time PCR assay facilitates assessment of hematopoietic chimerism

Stroke - Awareness low among women, especially minorities

Systemic Lupus Erythematosus - Rituximab induced remission from hypercoagulable state associated with LA

Tissue Engineering - Articular chondrocytes express phenotype in a collagen-containing sponge

Tissue Engineering - Mechanical load promotes osteoblastic stem cell proliferation in Col I matrix

Tissue Engineering - tHA ceramics support cell attachment/proliferation/differentiation

Transplant Medicine - Autoimmune hepatitis forms following orthotopic liver transplantation

Transplant Medicine - Cyclosporine A-based combo therapy ineffective in preventing bone rejection

Transplant Medicine - Kidney transplant recipients need to exercise, monitor diet

Transplant Medicine - Livers from older donors may harm transplant recipients with hepatitis C

Transplant Medicine - Unexplained hepatitis in renal graft recipients may be caused by hepatitis E

Tuberculosis - String test as sensitive as sputum induction for TB detection in HIV infection

Tuberculosis and Candida Coinfection - Candida coinfection higher in tuberculosis patients with complications

Umbilical Cord Blood Research - TGF-beta1 suppresses CTL differentiation of cord blood naive CD8+ cells

Variant Creutzfeldt-Jakob Disease - Model choices for variant Creutzfeldt-Jakob disease projections are problematic

Venous Thromboembolism - VTE incidence calculated among Factor V Leiden carriers

Virology - Researchers' findings advance virology research

West Nile Virus - Interferon can cure cells of West Nile virus replicons

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