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Embryonic Stem Cell Research

Cell-surface marker found on embryonic hepatoblasts

Published in Blood Weekly, April 7th, 2005

A cell-surface marker was found on embryonic hepatoblasts.

"The nature of the cells that contribute to the repopulation of the liver after hepatic necrosis or cirrhosis remains uncertain, in part because we lack specific markers to facilitate identification and prospective isolation of progenitor cells.

"The monoclonal antibody GCTM-5 reacts with a minority subpopulation of cells in spontaneously differentiating cultures of pluripotent human embryonal carcinoma or embryonic stem cells. The epitope recognized by GCTM-5 is found on a 50-kDa protein present on the surface of these cells," scientists in Australia report.

"In tissue...

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