Embryonic Stem Cell Research
Enforced PU.1 expression rescues osteoclastogenesis from ESCs lacking Tal-1
Published in Blood Weekly, April 7th, 2005
According to recent research published in the journal Stem Cells, "Transcription factor T-cell acute lymphocytic leukemia 1 (Tal-1) is essential for the specification of hematopoietic development. Mice lacking Tal1 fail to generate any hematopoietic precursors."
"Using our co-culture system with stromal cells, we demonstrate that enforced expression of the transcription factor PU.1 under tetracycline control in Tal1-null embryonic stem (ES) cells rescues the development of osteoclasts and macrophage-like phagocytes.
"It was low...
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Source: Blood Weekly (2005-04-07)
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