Published in Blood Weekly, April 7th, 2005
"High-level fluoroquinolone (FQ) resistance in Salmonella enterica serovar Typhimurium phage type DT204 has been previously shown to be essentially due to both multiple target gene mutations and active efflux by the AcrAB-TolC efflux system.
"In this study we show that in intermediatly resistant acrB-inactivated serovar Typhimurium DT204 mutants, high-level resistance to FQs can be restored on in vitro selection with FQs," researchers in France report.
"In each FQ- resistant mutant selected from serovar Typhimurium DT204 acrB mutant strains,"...
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