HIV/AIDS Drug Development
PNA-transportan conjugate targeted to HIV-1 TAR is antiviral and virucidal
Published in Blood Weekly, April 7th, 2005
"We have earlier reported that anti-TAR PNA conjugated with the membrane-transducing peptide transportan inhibits transactivation of the HIV-1 LTR resulting in decreased production of HIV-1 virions by chronically infected H9 cells (N. Kaushik et al. J Virol. 2002;76:3881-3891)," researchers in the United States report.
"In this study," wrote B. Chaubey and coworkers at the University of Medicine and Dentistry of New Jersey, "we have found that the PNA(TAR)-transportan conjugate is efficiently internalized by cells and kinetics analysis reveals a sigmoidal curve with a...
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Source: Blood Weekly (2005-04-07)
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