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HIV/AIDS Immune Activation

Use of HAART and other factors increase oxidative damage

Published in Blood Weekly, April 14th, 2005

The use of HAART and other factors increase oxidative damage.

According to a recent report from the United States, "In a cross-sectional study involving subjects from the Reaching for Excellence in Adolescent Health cohort, we examined the associations between HIV status, disease severity, immune activation, and oxidative damage.

"Subjects (265 HIV-positive and 127 HIV-negative) were young (range: 14-23 years of age) and primarily female (75%) and black (67%). Many subjects, particularly female subjects, were overweight or obese. Relatively few HIV-positive subjects had advanced HIV disease (13%), and 54% were taking antiretroviral therapy...

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