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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . April 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Safety - Blood supply remains unsafe in Latin America

Surgical Technology - Novel microfluidic device shows promise for blood washing

Tissue Engineering - Human platelet supernatant can lead to chondrocyte dedifferentiation

Tissue Engineering - Keratinocyte culture system developed for use in skin wound closure

Tissue Engineering - Vascular patches tissue-engineered with bone marrow-derived cells

Acute Myocardial Infarction - Access-site complications limited after rescue PCI during thrombolysis

Anthrax - Anthrax spores cleared from lungs between 8-14% per day

Apoptosis - Homeobox Msx1 interacts with p53 and inhibits tumor growth via apoptosis

Balloon Aortic Valvuloplasty - Antegrade transseptal approach improves outcome of percutaneous BAV

Bioterrorism -  Burkholderia species should be considered as possible agents of biowarfare

Bioterrorism - Data sources must be collected in timely manner for rapid bioterrism detection

HIV/AIDS Therapy - Researchers publish new studies and findings in the area of HIV/AIDS therapy

Blood Substitute - Biopharma company comments on funding of blood substitute clinical trial

Blood Substitute - Hemoglobin blood substitute used in critically anemic Jehovah Witness

Business Update - Blood Center of Iowa implements Surround 4.1 System

Business Update - Xeno stem cell supplier hires investor relations and communications firm

Cardiology - Protective effect of remote preconditioning is memorized in the explanted heart

Cardiovascular Research - Adrenomedullin improves cardiac function in rodents treated for infarction

Hematology - Studies describe new findings in hematology research

Clinical Trials - Medical diagnostics company signs dengue testing agreement with U.S. Navy

Cloning - Muslims distinguish between reproductive and therapeutic cloning

Colon Cancer Prevention - Green vegetables may decrease colon cancer risk

Colorectal Cancer - Cytomegalovirus not associated with colorectal tumorigenesis

Cord Blood Research - Legislation introduced to create inventory of cord blood stem cell units

Cryptosporidiosis - Cryptosporidiosis declines after membrane filtration of public water supply

Diagnostics - Pilot study of LymPro, a blood test for Alzheimer disease, launched

Drug Development - Humanized immunoenzyme targets B-cell lymphoma

Ebola Outbreak - Wild animal mortality monitoring predicts human Ebola outbreaks

Embryonic Development - HSCs restricted in their differentiation potential during embryo development

Embryonic Stem Cell Research - Embryonic stem cells are a source of dendritic cells for clinical applications

Embryonic Stem Cell Research - Two independent anatomical sites generate hematopoietic cells

Esophageal Candidiasis - Antifungal product for prophylaxis of Candida receives FDA approval

Finance - Dialysis provider announces pricing of senior notes, senior subordinated notes

Finance - Majority of shareholders reaffirm agreement to lock-up of stock, company says

Gastroenteritis Virus Detection - RT-PCR-based dot blot hybridization detects/differentiates PEDV and TGEV

Gene Transfer - Suicide gene therapy kills glioma cells using a bystander effect

Genetic Disorders - STR replacements in UTRs and introns associated with gene expression and disease

Glioma Therapy - Sequential high-dose chemotherapy suitable for pediatric patients

HIV/AIDS Biotechnology - LC/MS assay quantities NRTIs in biological matrices

HIV/AIDS Coinfection - Interactions between HIV and herpes viruses occur within the oral mucosa

HIV/AIDS Drug Adherence - Medication adherence training instrument assists persons living with HIV/AIDS

HIV/AIDS Drug Development - Betulinic acid derivatives inhibit HIV-1 fusion/interfere with HIV-1 maturation

HIV/AIDS Drug Development - Cellular deoxyhypusine synthase is a target for antiretroviral therapy

HIV/AIDS Drug Development - Pyridine N-oxide derivatives protects against HIV-induced CD4 cell destruction

HIV/AIDS Drug Resistance - HIV-1 mutations associated with reduced susceptibility identified in Brazil

HIV/AIDS Epidemiology - HLA-A11 associated with CTL response against HIV-1 Nef in exposed persons

HIV/AIDS Healthcare - Case management/shared-care schemes provide integrated care for HIV/AIDS

HIV/AIDS Pathogenesis - Endocytosis contributes to productive HIV entry

HIV/AIDS Pathogenesis - Heterogeneous selective pressures in env gene evolution among HIV-1 subtypes

HIV/AIDS Pathogenesis - Major coreceptors of HIV-2 variants identified from persons with/without viremia

HIV/AIDS Pathogenesis - Myristoyl moiety of HIV Nef involved in regulation of calmodulin interaction

HIV/AIDS Pathogenesis - Recent findings in HIV/AIDS pathogenesis provide new insights

HIV/AIDS Pathogenesis - Rodent cells support key functions of HIV-1 Nef

HIV/AIDS Pathogenesis - VCAM-1 expression on CD8+ cells correlates with enhanced anti-HIV suppression

HIV/AIDS Pathogenesis - Vif defects yield hypermutated genome that integrates but cannot produce progeny

HIV/AIDS Research - Covalent fusions with SlyD or FkpA solubilize retroviral Env proteins

HIV/AIDS Research - Researchers detail new studies and findings in the area of HIV/AIDS

HIV/AIDS Research - SP1 sequence mutation impairs HIV-1 Gag multimerization/membrane-binding

HIV/AIDS Research - Strong genetic signature exists for HIV-1 replication in male genital tract

HIV/AIDS Therapy - CSF HIV is an accessible surrogate for HIV virions in brain

HIV/AIDS Therapy - IL-7 induces latent HIV-1 cellular reservoirs of infected individuals on HAART

HIV/AIDS Therapy - Lymphocyte activation + RT inhibitors protect against retroviral disease

HIV/AIDS Therapy - Researchers provide details of new studies and findings in the area of HIV/AIDS therapy

HIV/AIDS Vaccine - SIV inactivated by N-ethylmaleimide with preservation of functional Env

HIV/AIDS-Related Metabolic Syndrome - Lipid-lowering drugs may cause pharmacokinetic interactions with antiretrovirals

HIV/AIDS-Tuberculosis Coinfection - Fas/Fas-ligand has role in immune modulation and pathogenesis of tuberculosis

HIV/AIDS-Tuberculosis Coinfection - Peripheral lymph node needle-core biopsies diagnose TB in HIV-infected adults

Heart Disease - Twin-to-twin transfusion syndrome presents an increased risk of adult disease

Heart Transplantation - Recombinant FVII used to control bleeding during RVAD implantation

Hematology - CS-ArgC is suggested as a promising anticoagulation biomaterial

Hematology - Cryopreserved umbilical cord blood yields mesenchymal stem cells

Hematology - Genetic testing sheds light on the several manifestations of hemochromatosis

Hematology - Reports describe recent advances in hematology research

Hematology - Stimulation of platelet production may provide a new management option for ITP

Hemodialysis - Study to examine link between nutrition, inflammation and ESA response

Hepatitis C - Study initiated to evaluate hepatitis C infection post liver transplant

Immune Activation - T cell defects arise from chronic Ag activation leading to rapid CD8+ cell aging

Infant Mortality - Second-born very low birth weight twins risk increased respiratory morbidity

Influenza A Virus - Avian influenza A subtype H7-infected pigeons multiply and excrete H7 viruses

Kidney Transplantation - Plasma exchange may prevent graft loss due to atypical HUS

Leishmaniasis - 71 strains from cutaneous leishmaniasis in Tunisia characterized

Leukemia - Genetically modified natural killer immune cells attack, kill leukemia cells

Leukemia Tumorigenesis - Evi3 expression in tumors altered level of EBF target genes in leukemia

Mergers & Acquisitions - Acquisition of Research Diagnostics Inc by biotech company completed

Mycobacterium Detection - Staining parameters determined to increase sensitivity of mycobacterial smears

Mycobacterium Diagnosis - PCR identifies nontuberculous mycobacteria from paraffin-embedded tissues

Mycobacterium tuberculosis - DC-SIGN differentiates between pathogenic and nonpathogenic mycobacteria

Myelodysplastic Syndrome - Darbepoetin alpha suitable for anemia treatment in low-intermediate risk MDS

Myocardial Infarction - Multipotent stem cells from bone marrow revitalize injured cardiac tissue

Myocardial Infarction - New findings in the area of myocardial infarction described

Neural Stem Cell Research - Estrogen promotes differentiation/survival of NSC-derived dopaminergic neurons

Neurotransmitter - Neurotransmitter conjugate activates membrane receptors

Nocardia brasiliensis - Patients with N. brasiliensis actinomycetoma have type Th2 immune response

Non-Hodgkin Lymphoma - NAT and GST polymorphisms don't appear linked to NHL

Oncology - Studies describe new findings in oncology research

Parkinson Disease - Dopaminergic neurons from monkey ESCs function in Parkinson primate model

Pediatric Oncology - Adenovirus hepatitis is fatal to children who receive chemotherapy for leukemia

Percutaneous Coronary Intervention - Closure devices may increase vascular complication risk

Personnel - Edward W. Wright appointed VP of marketing by medical monitoring devices company

Plague -  Yersinia pestis outbreak strains susceptible to antimicrobials

Pneumocystis Infection -  Pneumocystis outbreak transmitted within pediatric transplant unit

Pneumocystis Infection - General population may be a reservoir of Pneumocystis jirovecii

Polycythemia Vera - Cause of blood disorder found

Proteomics - PARP-1 may provide cardioprotection by regulating signal transduction pathways

Reperfusion - Post-reperfusion absorption studied, role of P-glycoprotein clarified

SARS - Quarantine for SARS indirectly reduces infections

SARS Coronavirus - Researchers' findings advance SARS coronavirus research

SARS Outbreak - SARS needs to be distinguished from other febrile respiratory illnesses

SARS Prevention - Findings describe new data in SARS prevention research

Stem Cell Research - ESC-derived atrial cardiomyocytes identified during early development

Stem Cell Research - Exposure to young systemic environment rejuvenates aged progenitor cells

Stem Cell Research - Genistein stimulates osteoblastic differentiation via NO/cGMP in bone marrow

Stem Cell Research - Germline stem cells resemble undifferentiated spermatogonia in adult testis

Stem Cell Research - Hematopoietic stem cells identified from dermal papillae of hair follicles

Stem Cell Research - High-field MRI allows tracking of minimal number of cells

Stem Cell Research - Human reaming debris is a source of multipotent stem cells

Stem Cell Research - Laminin-5 induces osteogenic gene expression in MSCs via ERK-dependent pathway

Stem Cell Research - Mechanisms controlling primordial germ cell proliferation in females explored

Stem Cell Research - Oct-4 may be crucial in SC property of spermatogonia but not in cell survival

Stem Cell Research - SCL enhancer directs oncogenic fusion genes into stem cells

Stem Cell Research - SP cells share transcriptome signatures/express tissue-specific markers

Stem Cell Research - T cells differentiated with anti-CD3/anti-CD28 in presence of TGF-beta

Stem Cell Transplantation - HLA antigens risk/protective factors for acute GVHD in HLA-identical SCT

Stem Cell Transplantation - RT-PCR enables pre-emptive management of EBV reactivation after ASCT

Stem Cell Transplantation - cDNA library identifies HLA class II-restricted peptides recognized by CD4 cells

Systemic Inflammatory Response Syndrome - CV abnormalities can be identified at bedside for pharmacologic management

Thrombophilia & Cancer - Condition of thrombophilia in cancer explored

Tissue Engineering - Bone repair with form of BMP-2 incorporates into fibrin cell ingrowth matrices

Tissue Engineering - Ceramic implants induce more bone formation than titanium implants

Tissue Engineering - Hyaluronic acid used to coat surfaces through direct immobilization

Tissue Engineering - Modified biodegradable scaffolds used for cartilage tissue engineering

Tissue Engineering - PLG microspheres are a moldable scaffold for cartilage tissue engineering

Tissue Engineering - Peptide-immobilized nanoporous alumina membranes enhance osteoblast adhesion

Tissue Engineering - Self-gelling hydrogels are based on oppositely charged dextran microspheres

Tissue Engineering - Tissue engineering schemes developed by artificial intelligence

Transplant Medicine - Behavior of transplanted bone marrow-derived GFP mesenchymal cells defined

Transplant Medicine - Combined therapy stems hepatitis B recurrence in liver transplant patients

Transplant Medicine - Human adipose stromal cells can be differentiated into hepatocytes

Transplant Medicine - Liver donor-specific IFN-gamma-producing cells denote HCV recurrence risk

Transplant Medicine - Longest surviving artificial heart patient marks 5 years on miniature device

Transplant Medicine - Marrow transplants from matched unrelated donors allow stable engrafment

Tuberculosis - Fixed dose combinations for TB helps prevent emergence of drug resistance

Tuberculosis - Pathogen-induced microenvironments exist within host cell endosomal system

Tuberculosis - Proportion method for drug resistant-TB determination not supported by research

Tuberculosis - Pyrosequencing differentiates between M. tuberculosis complex species

Tuberculosis - TB group, GlaxoSmithKline announce joint drug discovery program for TV therapies

Tuberculosis Control - Tuberculosis control programs in China may exclude poor people

Tuberculosis Diagnostics - Heat-fixed unstained sputum AFB smears stable up to 10 months

Tuberculosis Therapy - Diamine-based antituberculosis drug inhibits intracellular M. tuberculosis

Tuberculosis Therapy - Majority of MDR-TB isolates in Thailand susceptible to second-line drugs

Tuberculosis Treatment - Melatonin prevents free radical/MADD metabolic profiles induced by anti-TB drugs

Virology - Type of application defines the value of hepatitis C genotyping methods

West Nile Virus - Moroccan West Nile virus isolates related to equine outbreaks in Mediterranean

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