Leukemia Tumorigenesis

Evi3 expression in tumors altered level of EBF target genes in leukemia

Published in Blood Weekly, April 21st, 2005

Scientists suggested that ecotropic viral insertion site 3 (Evi3) expression in tumors altered the level of Early B-cell Factor (EBF) target genes in leukemia.

According to recent research from the United States, "Retroviral insertions that activate proto-oncogenes are a primary cause of tumors in certain strains of mice. The AKXD recombinant inbred mice are predisposed to a variety of leukemias and lymphomas as a result of viral integration. One common insertion site, the Evi3, has been implicated in most B-cell tumors in the AKXD-27 strain."

"The Evi3 gene encodes a zinc-finger protein with sequence similarity to the Early B-cell Factor-Associated...

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Source: Blood Weekly (2005-04-21)

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