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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . May 5th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Osteopetrosis - High peripheral blood SCs enable autologous backup before SCT for osteopetrosis

Stem Cell Transplantation - ABO incompatibility does not affect clinical outcome after APBSCT

Stem Cell Transplantation - Circulating DC subsets post-ASCT correlate with acute GVHD severity in children

Tissue Engineering - Bovine collagen constructs used to reconstruct full-thickness scalp defects

Acinetobacter Outbreaks -  Acinetobacter baumannii nosocomial outbreak strain produces PER-1 ESBL

African Swine Fever - Invader assay adapted for African swine fever virus DNA detection

Androgen Receptor - Notch signaling mediator Hey1 is an androgen receptor corepressor

Antiviral Drug Development - Understanding viral life cycles crucial to exploit antiviral strategies

Apoptosis - Annexin A5 analyzed, downregulation of tissue factor expression revealed

Apoptosis - p53 has crucial role in signal transduction pathways of silica-induced apoptosis

Arthritis - Pharma co receives U.S. FDA clearance for injured tissue stem cell therapy trial

Bacille Calmette-Guerin Infection - PB/BM findings described in disseminated bacille Calmette-Guerin infection

Bacteriology -  M. gastri cause of disseminated infection in children of same family

Bacteriology - PCR detects and quantitates benzoyl-CoA reductase genes from bacteria

Biomedical Engineering - Technological advances exploited to engineer cardiac tissue

Blood Supply - African American Pastors' Coalition partners to hold blood drives in Texas

Bone Marrow Transplantation - Early VRE infection post-BMT associated with rapid deteriorating clinical course

Breast Cancer - Ki67 breast cancer marker correlates with regulation of apoptosis-related genes

Breast Cancer - Methyl mercury influences growth-related signaling in breast cancer cells

Breast Cancer - Real-time PCR measures Epstein-Barr virus DNA in archival breast adenocarcinomas

Business Update - "Research use only" ETP assay now available

Business Update - CordLife opens banking facility in Hong Kong

Cancer Genetics & Genomics - Single-round PCR assay detects BCL2-IGH

Cancer Inhibitor - Leukemia inhibitory factor receptor characterized in goldfish

Cancer Prevention - Anthocyanidins from fruits and vegetables inhibit tumor cell growth

Cancer Therapy - Researchers' findings advance cancer therapy research

Cardiac Surgery - Autologous blood predonation with erythropoietin avoids homologous transfusion

Cardiac Surgery - Symptomatic cerebrovascular accidents are rare following the Fontan procedure

Cardiology - Octylguanidine protects against damage induced by ischemia-reperfusion

Chikungunya Virus - RT-PCR without RNA extraction detects/quantifies African Chikungunya viruses

Cholera Epidemics - Seasonal cholera epidemics inversely correlate with cholera phage prevalence

Chronic Myeloid Leukemia - Recent approaches to CML interrupt key signaling pathways activated by Bcr-Abl

Clinical Trials - Clot buster enters Phase II stroke trial

Collaborations - Curis announces second major collaboration

Colon Cancer - Curcumin inhibits colon cancer via PPARgamma activation

Colon Cancer - Gastrin promotes colon cancer via CCK-2 receptor-mediated COX-2 induction

Colon Cancer - Quercetin inhibits beta-catenin/Tcf signaling in colon cancer cells

Colorectal Cancer - n596 gene deletion causes hereditary nonpolyposis colorectal cancer

Contraceptive Microbicide - Contraceptive microbicide nonoxynol-9 has deleterious effects on endometrium

Cutaneous Tuberculosis - Tuberculosis verrucosa cutis results in fixed-flexion deformity of arm

Diagnostics - EPIX initiates phase II trial of EP-2104R for blood-clot detection using MRI

Diagnostics - Flow cytometry detects circulating endothelial cells and their progenitors

Diagnostics - PCR-RFLP discriminates Campylobacter jejuni strains

Diet & Nutrition - Elemental diet improves nutritional recovery from diarrhea/malnutrition

Drug Development - Biopharma company confirms scale up of Cascade technology for plasma proteins

Drug Development - Glycerophosphoinositols inhibit tumor cells from invading extracellular matrix

Embryonic Stem Cell Research - Embryonic stem cells generate airway epithelial tissue

Epidemiology - Multidrug-resistant A. baumannii outbreak confined to ICU and surgical ward

Epidemiology - Nosocomial outbreak investigation database developed

Epstein-Barr Virus - Epstein-Barr virus dUTPase upregulates the production of TNF-alpha

Finance - Automated instrument-reagent systems trigger record third quarter results

Gene Research - Genetic elements affect susceptibility to hemolytic uremic syndrome

HIV-2 Epidemiology - SIVsm strains isolated from Sierra Leone bush meat highly divergent from HIV-2

HIV/AIDS & Syphilis Coinfection - Seronegative syphilis in HIV patient tests positive by dark field examination

HIV/AIDS Diagnostics - Early response to antiretroviral treatment predicts long-term response

HIV/AIDS Diagnostics - NucliSens EasyQ correlates with Roche Amplicor in monitoring HIV-1 RNA in Africa

HIV/AIDS Diagnostics - Sensitive PCR estimates HIV-1 in CD4+ cells in patients responding to HAART

HIV/AIDS Drug Development - CCR5 antagonist suppresses replication/CPE in HIV-infected mouse model

HIV/AIDS Drug Interactions - Antiretrovirals often interact with medications for OIs and primary care

HIV/AIDS Drug Resistance - Recent findings in HIV/AIDS drug resistance described

HIV/AIDS Epidemic - Assay screens HIV-1 in epidemics characterized by mono/dual clade predominance

HIV/AIDS HAART - High blood lipids observed with PIs increase 10-year coronary risk

HIV/AIDS Healthcare - Treatment-seeking behavior same in HIV/AIDS orphans/nonorphans in Kampala

HIV/AIDS Pathogenesis - APOBEC3G antiviral function can dissociate from cytidine deaminase activity

HIV/AIDS Pathogenesis - HIV-1 catalytic core domain residues important for HIV-1 replication/integration

HIV/AIDS Pathogenesis - HIV-1 clade promoters strongly influence replication spatial/temporal dynamics

HIV/AIDS Pathogenesis - HIV-1-specific CD4+ cell turnover and activation increase upon viral rebound

HIV/AIDS Pathogenesis - POSH is essential for HIV-1 production

HIV/AIDS Pathogenesis - Unintegrated HIV-1 reservoir in recently infected resting CD4+ cells very labile

HIV/AIDS Pediatrics - Infants are increasingly exposed antiretrovirals even from conception

HIV/AIDS Research - "Preloaded" natural killer cells efficiently lyse HIV-infected target cells

HIV/AIDS Research - Quantitation of RT-PCR defective/ecotropic viruses in murine AIDS

HIV/AIDS Risk Behavior - Puerto Rican crack users in Puerto Rico have riskier sex than those in New York

HIV/AIDS Therapy - Lethal mutagenesis may be used to extinguish HIV infection

HIV/AIDS Therapy - NNRTIs and RNase H inhibitors given in same HAART regimen may be beneficial

HIV/AIDS Therapy - Older antiretroviral strategies show renewed interest

HIV/AIDS Vaccine - Segments of consecutive AA residues of HIV gp120 proposed as vaccine candidates

HIV/AIDS-Associated Emphysema - AIDS-associated emphysema due in part to HIV-1 infection of alveolar macrophages

HIV/AIDS-Epidemiology - High HSV-2/HHV-8 in remote area belies behavior that may facilitate HIV spread

HIV/AIDS-Related Hodgkin Lymphoma - LMP-1 deletion mutants highly associated with HIV-related Hodgkin's lymphoma

Helicobacter Pylori -  H. pylori infection correlates with DNA damage in gastric mucosa cells

Hematology - Findings describe new data in hematology research

Hematology - Major functional genes become deregulated in acute myeloid leukemia subtypes

Hematology - Platelet count can predict development of heparin-dependent antibodies

High-Intensity Focused Ultrasound - Erythrocytes and microbubble contrast agents improve thermal HIFU effects

Hodgkin Disease - Prognostic model for outcome of stem-cell transplantation developed

Human Papillomavirus-Associated Cancer - HPV strongly associated with several cancers independent of HIV infection

Immunology - Study investigated dendritic cell distribution after heart transplantation

Immunotherapy - Pre-emptive immunotherapy prevents relapse in children with MDS after ASCT

Influenza Virus - Avian influenza strain causes lethal systemic infections in ferrets

Ischemia - Administration of ET-1 before ischemia results in a cardioprotective effect

Ischemia - Fibrin-derived peptide B beta(15-42) studied, myocardial protection noted

Ischemia - Study examined contribution of Na+ overload to ischemia-reperfusion injury

Juvenile Myelomonocytic Leukemia - Trend towards graft-versus-leukemia in juvenile myelomonocytic leukemia in ABMT

Legal Issues - Dialysis products company announces receipt of subpoena

Leukemia - AS132 targeted specific proteins for destruction by the proteasome in leukemia

Leukemia - Distinct gene expression patterns linked to FLT3- and NRAS-activating mutations

Leukemia - Eight twenty-one homologues expressed during hematopoietic differentiation

Leukemia - New aspects of chronic lymphocytic leukemia reviewed

Leukemia - Pomolic acid triggered mitochondria-dependent apoptotic cell death in leukemia

Leukemia - SUMO-1 binding required for modification and colocalization with leukemia

Leukemia - SUMO-1 promoted association of SNURF (RNF4) with PML nuclear bodies

Listeria Monocytogenes - Black seed oil inhibits Listeria monocytogenes

Lung Cancer - Glucocorticoids induce 15-PGDH in lung adenocarcinoma cells

Lung Injury Biomarker - Elevated sTNF receptors associated with morbidity/mortality in acute lung injury

Lupus Vulgaris - Misdiagnosis can result in severe skin lesions in lupus vulgaris

Major Depressive Disorder - Hypoalbuminemia may be useful in diagnosis

Mergers & Acquisitions - Biotechnology company acquires Cengent Therapeutics, Inc.

Methadone-Related Rash Outbreaks - Syndromic rash outbreaks affected methadone clinic patients in New South Wales

Myeloma - New, improved staging system effective for multiple myeloma

Nerve Regeneration - Nerve guidance system developed for nerve regeneration/functional recovery

Neuroscience - Biodegradable genipin-cross-linked gelatin conduit material evaluated

Obstetrics - Pregnancy complications related to low levels of anti-clotting proteins

Osteocarcoma - PAF receptor antagonist potent/cytotoxic Ca2+ mobilizer in osteosarcoma cells

Pediatric Leukemia - Spatial analysis of childhood leukemia performed in a case/control study

Peritoneal Dialysis - Rapamycin guides the epithelial-to-mesenchymal transition of peritoneal cells

Personnel - Heart surgeon appointed chair of cardiothoracic surgery at Montefiore Medical

Personnel - James Stewart named chief financial officer by stem cell-focused biotech company

Personnel - Network of nonprofit blood centers names president

Personnel - Neuroscientist and senior NIH administrator fills key scientific post

Pharmaceutical Research - SonoLysis shows promise as a declotting agent for dialysis patients

Product Licensing - Genomics company obtains exclusive license to develop new anemia drug

Pulmonary Medicine - Researchers identify new clinical syndrome caused by hemolysis

Regulatory Issues - Report proposes structure for national network of cord blood stem cell banks

Renal Transplantation - Urinary beta 2-microglobulin studied, cleavage identified

SARS Coronavirus - Reports describe recent advances in SARS coronavirus research

Sclerosing Encapsulating Peritonitis - Clinical features of dialysis-related SEP characterized

Septicemia - Postmortem markers of sepsis studied, serial monitoring reported

Sickle Cell Disease - Long-term outcome determined for children with elevated velocities on TCD

Simian T-Cell Lymphotropic Virus Type 1 - Africa is origin of Tulane primate center STLV-1 sooty mangabey strain

Skin Cancer - 1,25-Dihydroxyvitamin D-3 and analogues protect against UVB-induced DNA damage

Stem Cell Research - A new embryonic stem cell line encodes a key cystic fibrosis mutation

Stem Cell Research - Bone marrow-derived stem cells contribute little to human tumor vessel growth

Stem Cell Research - Hes1 has inhibitory role in Paneth cell differentiation in small intestine

Stem Cell Research - LIF induces kidney stem-like cell multilineage differentiation via cadherin 16

Stem Cell Research - Prolonged-survival neonatal PMNs have enhanced inflammatory/cytotoxic response

Stem Cell Research - Research needed to determine efficient delivery of SCs to appropriate sites

Stem Cell Research - SVP modifies self-renewal SC program to allow chronological change of cell fates

Stem Cell Research - Sonic hedgehog controls stem cell behavior in postnatal and adult brain

Stem Cell Research - VEGF helps embryonic stem cells survive hypoxic stress

Stem Cell Research - alpha1LG4-5 provides vital signals for SC conversion to polarized epithelium

Stem Cell Research - c-Myb and p300 regulate stem cell proliferation and hematopoiesis

Stem Cell Transplantation - Back-up donor identification saves time in unrelated stem cell transplantation

Stem Cell Transplantation - PBSC graft composition affects outcomes after nonmyeloablative conditioning

Stem Cell Transplantation - Relaxation breathing does not improve leukocyte numbers in AHSCT

Stem-Cell Transplantation - Recent findings illuminate research in stem-cell transplantation

Stem-Cell Transplantation - Retinoic acid may heighten risk of bone marrow transplant nephropathy

Suicidal Behavior Gene - Serotonin synthesis genes involved in predisposition to suicidal behavior

Thrombosis - Autoimmune hepatitis accompanies antiphospholipid syndrome

Tissue Engineering - Studies advance knowledge in tissue engineering research

Transplant Medicine - Heart and Lung Transplant Society marks 25 years

Transplant Medicine - New technology helps heart and lung patients awaiting transplants

Transplant Medicine - Noninvasive test to determines risk of rejection in heart transplant patients

Transplant Medicine - Studies add new findings to transplant medicine body of knowledge

Transplant Medicine - VEGF expansion elicits poor long-term outcomes in renal graft recipients

Tuberculosis - Two sputum specimens adequate for pulmonary tuberculosis diagnosis

Umbilical Cord Blood - CB chromosomal aberrations associated with prenatal exposure to carcinogenic PAH

Vascular Graft - Procedure developed to extract RNA from cells seeded onto cylindrical conduits

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