Lung Cancer
Glucocorticoids induce 15-PGDH in lung adenocarcinoma cells
Published in Blood Weekly, May 5th, 2005
"Dexamethasone induced the expression of 15-PGDH in a time- and concentration-dependent manner in A549 human lung adenocarcinoma cells. Maximal induction was observed at 10nM. Induction of 15-PGDH expression was also achieved by other synthetic glucocorticoids," scientists in the United States report.
"Induction was inhibited by the addition of proinflammatory cytokines and phorbol ester. These pro-inflammatory agents were also shown to induce COX-2 expression.
"PMA was found to be the most effective stimulator of COX-2 expression and the most potent inhibitor of...
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Source: Blood Weekly (2005-05-05)
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