Osteopetrosis
High peripheral blood SCs enable autologous backup before SCT for osteopetrosis
Published in Blood Weekly, May 5th, 2005
"Autosomal recessive osteopetrosis (OP) is a rare, lethal disorder in which osteoclasts are absent or nonfunctional, resulting in a bone marrow cavity insufficient to support hematopoiesis.
"Because osteoclasts are derived from hematopoietic precursors, allogeneic hematopoietic cell transplantation can cure the bony manifestations of the disorder. However, high rates of graft failure have been observed in this population. It is not possible to harvest bone marrow from these patients for reinfusion should graft failure be...
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Source: Blood Weekly (2005-05-05)
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