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Stem Cell Transplantation

Circulating DC subsets post-ASCT correlate with acute GVHD severity in children

Published in Blood Weekly, May 5th, 2005

Circulating dendritic cell subsets following allogeneic stem cell transplantation correlate with acute graft-versus-host disease severity in children.

According to a study from Finland, "We examined the recovery of circulating monocytoid (Lin- CD11+HLA-DR+ and plasmacytoid (Lin- CD123+HLA-DR+) precursor (pre)dendritic cell (DC) subsets after allogeneic stem cell transplantation (SCT) in 39 children, using age-matched healthy children as controls. The frequencies of DCs in peripheral blood samples were determined by flow cytometry."

"The initial recovery of DC occurred simultaneously with myeloid engraftment. However, with time, DC subset values...

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