Androgen Receptor
Notch signaling mediator Hey1 is an androgen receptor corepressor
Published in Blood Weekly, May 5th, 2005
"Hey1 is a member of the basic helix-loop-helix-Orange family of transcriptional repressors that mediate Notch signaling.
"Here we show that transcription from androgen-dependent target genes is inhibited by Hey1 and that expression of a constitutively active form of Notch is capable of repressing transactivation by the endogenous androgen receptor (AR)," investigators in Spain report.
"Our results indicate that Hey1 functions as a corepressor for AF1 in the AR, providing a mechanism for cross talk between Notch and androgen-signaling pathways," said B. Belandia...
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Source: Blood Weekly (2005-05-05)
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