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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . May 12th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Artificial Blood Substitute - Liposome-encapsulated actin-Hb used to develop artificial blood substitutes

Blood Safety - Sterile filtration method removes poxvirus from plasma derivatives

Stem Cell Differentiation - Complex extracellular matrices promote tissue-specific stem cell differentiation

Tissue Engineering - Altering scaffolding materials yields optimal MSC-induced bone formation

Transfusion Medicine - Prestorage leucodepletion reduces transfusion reactions events

Acute Mixed Lineage Leukemia - Higher IAP expression associated with chemotherapy-resistant nature of AMLL

Acute Myeloid Leukemia - Arsenic trioxide represses activation of NF-kappa B/COX-2 in AML cells

Acute Myeloid Leukemia - New findings in the area of acute myeloid leukemia described

Angiology - Neurotrophins recruit and mobilize cells to enhance vessel formation

Angiology - Researchers provide details of new studies and findings in the area of angiology

Angiology - Researchers report details of new studies and findings in the area of angiology

Anticancer Therapy - Jasmonates act directly and selectively on cancer cell mitochondria

Apoptosis - Bax and Bak genes required for apoptosis induction by sulforaphane

Apoptosis - CD44 has a modulating role in death receptor-mediated apoptosis

Apoptosis - Cyclooxygenase-2 inhibits ginseng metabolite-mediated apoptosis

Avian Influenza - Avian flu outbreak control integrated human & veterinary health response efforts

Bacteriology -  Yersinia species survive and multiply in macrophage phagosomes

SARS - Researchers' work adds to SARS body of knowledge

Biomaterials - Clotting time shortened for HUVECs cocultured with biomaterial-treated monocytes

Biomedical Engineering - Gelatin conduit can be an effective aid for regenerating nerves

Bioterrorism - Multiplexed PCR assay simultaneously detects four biothreat agents

Blood Safety - Committee recommends PolyHeme phase III study continue

Blood Safety - People's Republic of China signs pact with blood safety organization

Brain Cancer - Cyclopamine inhibits tumor growth in brain

Brain Cancer - Mobile phone use not associated with risk of parietal/temporal lobe brain tumors

Breast Cancer - BCAS2 potentiates estrogen receptor transcriptional activity

Breast Cancer - BRCA1/2 germline mutations evaluated in breast cancer moderate/low-risk persons

Business Update - Cell-therapy company strengthens ties with Wisconsin Alumni Research

Business Update - HIV/AIDS report features Hemopurifier developer

Cardiology - Independent studies substantiate biocompatibility of stent coating technology

Cardioprotection - Preischemic administration of trimetazidine protects against I/R injury

Cardioprotection - Pyrroloquinoline quinone is a highly effective cardioprotective agent

Chondrogenesis - PGC-1 alpha regulates chondrogenesis via Sox9 gene association

Clostridium Difficile - slpA gene sequenced from C. difficile strains causing outbreaks in Japan

Collaborations - Companies collaborate on Virtual-Loop technology for type 1 diabetes

Colon Cancer - Short-term risk for colonic polyps in I1307K APC mutation is low

DNA Research - New advances made in DNA damage response network of Fanconi's anemia proteins

Diagnostics - PCR detects pathogenic leptospires earlier than in tissue culture

Diagnostics - Specific dinucleotide repeats identify hemophilia A carriers

Diagnostics - Toxigenic culture sensitive for diagnosis of C. difficile-assoc. diarrhea

Disseminated Tuberculosis - Disseminated TB presented as multiple hepatosplenic microabscesses/pancytopenia

Drug Delivery - PCL-based honeycomb scaffolds developed as drug delivery systems for rhBMP-2

Drug Development - Developed pyrrole derivatives have antimycobacterial activity

Drug Development - Oligosaccharides weak inhibitors of mycobacterial arabinosyltransferases

Enteric Infections - Rifaximin active against enteric infections

Epidemiology - Multiple C. difficile strains in fecal samples limits epidemiology studies

Genetics & Genomics - Commensal Escherichia coli strain harbors many 'virulence-associated' genes

Genetics & Genomics - Molecular elucidation of CML pathogenesis facilitates diagnosis and treatment

Genetics & Genomics - O-specific LPS gene cluster identified in CF-associated B. cenocepacia

Germ Cell Cancer - PARP-1 gene alterations found in germ cell tumors

Graft-Versus-Host Disease - APC requirements are different between CD8 and CD4-mediated acute GVHD

HIV/AIDS Drug Development - HIV receptor site interactions with metallocyclams investigated

HIV/AIDS Drug Development - High-throughput modified ELISA screens HIV-1 pg41 fusion inhibitors

HIV/AIDS Drug Development - NNRTI derivatives more potent against HIV-1 than efavirenz

HIV/AIDS Drug Development - Sulfonated naphthyl porphyrins active against HIV-1

HIV/AIDS Drug Development - Trimeric membrane-anchored gp41 inhibits HIV membrane fusion

HIV/AIDS Mental Health - Apathy correlates with cognitive function but not CD4 status in HIV infection

HIV/AIDS Pathogenesis - B30.2(SPRY) domain is the major determinant of anti-HIV-1 potency

HIV/AIDS Pathogenesis - HIV-1 Nef reduces rate of recycling of transferrin receptor to plasma membrane

HIV/AIDS Pathogenesis - HIV-1 Tat stimulates TC assembly through TBP recruitment in absence of TAFs

HIV/AIDS Pathogenesis - HIV-1 Vpr binds to 14-3-3 proteins and facilitates complex formation with Cdc25C

HIV/AIDS Pathogenesis - HIV-1 causes cell death via HIV-1 Vpr derived C terminal peptide

HIV/AIDS Pathogenesis - Interleukin-7 increases HIV-1 LAI-mediated Fas-induced T-cell death

HIV/AIDS Pathogenesis - Preferential apoptosis of HIV-1-specific CD4+ cells in HIV-infected persons

HIV/AIDS Pathogenesis - SATBI interacts with Tat in HIV-1-infected T cells

HIV/AIDS Research - Research in HIV/AIDS provides new insights

HIV/AIDS Vaccine - Anti-HIV Abs induced to control viremia via complement-mediated inactivation

Hair Studies - Eumelanin hair pigment preserved in proopiomelanocortin-deficient mice

Hematology - Postmortem molecular testing for hereditary thrombophilias may aid relatives

Hematology - Researchers' findings advance hematology research

Hematology - Serum markers herald thrombosis risk in patients with relapsed myeloma

Hematopoiesis - Cell signaling influences SC and its niche in rapidly self-renewing epithelia

Hematopoiesis - Growth factor independence 1 is an intrinsic regulator of stem cell self-renewal

Hematopoiesis - New findings in the area of hematopoiesis detailed

Hematopoiesis - Skeletal muscle is a reservoir for hematopoietic stem cells

Hemodialysis - Tacrolimus 0.1% ointment not effective for dialysis-related pruritis

Hemophilia - Gene therapy completely corrects hemophilia in laboratory animals

Hormone Replacement Therapy - HRT shouldn't be recommended solely to prevent cardiovascular disease

Information Technology - Mobile messaging technology company announces channel partner

Ischemia - Proteins in highly soluble fraction may contribute to cardioprotection

Kaposi Sarcoma-Associated Herpesvirus - KSHV LANA protects lymphoid cells from p16 INK4A-induced cell cycle arrest

Kidney Transplantation - Adenosine increase may be relevant for anti-ischemia and tissue protection

Leukemia - Cognitive changes in children treated for acute lymphoblastic leukemia

Leukemia - Gene expression pattern predicts multiple drug resistance, treatment failure

Leukemia - Leukemia-associated fusion proteins showed multiple paths of cell transformation

Leukemia - Methylation of histones in leukemia used as marker of granulocyte abnormalities

Listeria Diagnostics - Standardization needed for L. monocytogenes detection

Liver Cancer - Additional doxorubicin therapy doesn't improve outcome after liver transplant

Liver Regeneration - Embryonic STO cell-derived xenografts express hepatocytic functions.

Lymphoma - Histone deacetylase inhibitors induce apoptosis in t(14;18) lymphomas

Malaria - TOMOCOMD-CARDD approach identifies antimalarial compounds

Malaria Epidemic - Link between climate variability and malaria epidemics still unproven

Multiple Myeloma - Foundation advances research in myeloma with creation of tissue bank

Mycobacterium Tuberculosis - MTB & M. smegmatis mutants increased beta-lactam antibiotic susceptibility

Mycobacterium Tuberculosis - MTB evades host antimicrobial defenses by inhibiting phagosome maturation

Mycobacterium Tuberculosis - Molecular techniques differentiate MTB strains by genetic polymorphisms

Mycobacterium Tuberculosis - Pathway critical for MTB virulence conserved & functional in M. smegmatis

Mycobacterium Tuberculosis - Peptidoglycan hydrolase Cw1M identified in Mycobacterium tuberculosis

Myelodysplastic Syndromes - REVLIMID new drug application submitted to U.S. FDA for review

Myocardial Infarction - Sodium nitrite gets new medical uses for heart attack and organ damage

Neuritogenesis - Neuritogenesis modulated by topography and nerve growth factor

Neurogenesis - Beta-catenin mediated Wnt signal required to maintain pallium molecular identity

Nosocomial Infections -  L. pneumophila persist in water supply regardless of disinfection procedures

Nosocomial Infections - Nosocomial outbreak-related respiratory pathogens reviewed

Oncology - Researchers describe findings in oncology studies

Oral and Maxillofacial Surgery - Platelet-rich plasma doesn't improve outcome of cranial bone grafts

Proteome - Global effects of BCR/ABL and TEL/PDGFR beta expression on the proteome detailed

Proteomics - Rv3676 protein naturally defective in Mycobacterium bovis BCG strains

Proteomics - The serine/threonine kinase pim-1 has multifunctional properties

Psittacosis Outbreaks - Psittacosis outbreak may be linked to wild birds

Pulmonary Medicine - Combined cell and gene therapy remedies pulmonary hypertension

Renal Transplantation - Gene expression of proinflammatories is augmented in kidneys from NHB donors

SARS Coronavirus - SARSCoV mutation rates correlate with geographic epidemic characteristics

SARS Coronavirus - Safe & sensitive Spike protein-based IFA detects antibody responses to SARS-CoV

Simian Immunodeficiency Virus - Unliganded/fully glycosylated SIV gp120 structure determined

Staphylococcus Aureus -  S. aureus nasal carriage not assoc. with Vitamin D receptor gene mutation

Stem Cell Research - Cell line developed to study germ line stem cell biology

Stem Cell Research - Early fetal liver readily repopulates B lymphopoiesis in adult bone marrow

Stem Cell Research - Embryonic stem cell neural induction generates dopamine neurons

Stem Cell Research - G-CSF-induced uPAR upregulation associated with increased uPAR shedding

Stem Cell Research - Galectin-1 increases granulocyte-macrophage/erythroid colonies

Stem Cell Research - Menin suppresses osteoblast differentiation by antagonizing AP-1 factor JunD

Stem Cell Research - Neuroblast marking provides a tool for exploring neural stem cell genetics

Stem Cell Research - Neuropoiesis results in abnormal nestin/GFAP expression in intracranial glioma

Stem Cell Research - Neurulation protein CECR2 forms a chromatin remodeling complex with SNF2L

Stem Cell Research - SCF synergistically enhances TPO-induced STAT5 signaling in megakaryocyte SCs

Stem Cell Research - Stat3 negatively regulates G-CSF signaling by inducing SOCS3 expression

Stem Cell Research - Transcriptome profiling identifies divergent paths required to maintain SC state

Stroke - eNOS stimulates reparative growth factors following cerebral ischemia

Tissue Engineering - Anionic hydrogels improve cell adhesion and proliferation

Tissue Engineering - Chondrocyte endochondral ossification influenced by polyester crystallinity

Tissue Engineering - MSC osteogenesis influenced by sponge composition of gelatin/betaTCP scaffolds

Tissue Engineering - Method developed to pattern proteins & cells on PLA/PLGA for tissue engineering

Tobacco Use - Diet and tobacco exposure to acrylamide influence hemoglobin AA-adduct levels

Transplant Medicine - ABCB1 haplotypes influence tacrolimus levels in lung transplant patients

Transplant Medicine - Data advance knowledge in transplant medicine research

Transplant Medicine - Data: CyIS improves long-term survival in lung-transplant patients

Transplant Medicine - Pediatric immune systems study to improve young transplant patients' treatments

Tuberculosis - Isoniazid binds to NAT enzyme in mycobacterial cells

Tuberculosis Diagnosis - Culture more sensitive than PCR for extrapulmonary tuberculosis diagnosis

Tuberculosis Drug Development -  Quinchamalium majus constituents have potential antitubercular activity

Tuberculosis Vaccine - Prescreening program tested a wide range of tuberculosis vaccines

Tumor Invasion - Mammary ducts showed a different frequency of white blood cell infiltration

Tumor Suppression - Rb tumor suppressor in stress responses and hematopoietic homeostasis analyzed

Urogenital Cancer - Immunogenetic basis for high urogenital cancer prevalence in sea lions

West Nile Virus - Studies describe new findings in west nile virus research

Yersinia - Invasin triggers Rac1-mediated signals enabling Yersinia internalization

Yersinia - LAT/SLP-76 molecules targeted by Yersinia to inhibit T cell activation

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