Yersinia
LAT/SLP-76 molecules targeted by Yersinia to inhibit T cell activation
Published in Blood Weekly, May 12th, 2005
According to a study from the United States, "T cell responses are critical to the survival of Yersinia-infected animals. Yersinia have the ability to directly suppress T lymphocyte activation through the virulence factor YopH, a tyrosine phosphatase.
"Using single cell video microscopy and FACS analysis, here we show that even an average of one Yersinia per T cell is sufficient to inhibit or alter T cell responses."
"This efficient inhibition is traced to specific targeting by YopH of the adaptor proteins, linker...
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Source: Blood Weekly (2005-05-12)
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