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Biomaterials

Clotting time shortened for HUVECs cocultured with biomaterial-treated monocytes

Published in Blood Weekly, May 12th, 2005

Clotting time was shortened for human umbilical vein endothelial cells cocultured with biomaterial-treated monocytes.

Scientists in the United States report, "Understanding endothelial cell (EC)/blood/biomaterial interactions is crucial for the advancement of cardiovascular devices that often fail because of the lack of nonthrombogenic biomaterials.

"To begin to assess these interactions, a static EC/blood cell/biomaterial model was used. Isolated blood cells were pretreated with model biomaterial beads with different surface chemistries: polystyrene (PS), and PS beads grafted with 3-kDa polyethylene glycol (PEG) with either a hydroxyl (PS-PEG-OH) or...

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