HIV/AIDS Pathogenesis
HIV-1 Nef reduces rate of recycling of transferrin receptor to plasma membrane
Published in Blood Weekly, May 12th, 2005
"Human immunodeficiency virus type 1 (HIV-1) Nef interacts with the clathrin-associated AP-1 and AP-3 adaptor complexes, stabilizing their association with endosomal membranes. These findings led us to hypothesize a general impact of this viral protein on the endosomal system.
"Here, we have shown that Nef specifically disturbs the morphology of the early/recycling compartment, inducing a redistribution of early endosomal markers and a shortening of the tubular recycling endosomal structures," scientists in France report.
"Furthermore,"...
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Source: Blood Weekly (2005-05-12)
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